| Gene Symbol | DHRS2 |
|---|---|
| Entrez Gene | 10202 |
| Alt Symbol | HEP27, SDR25C1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dehydrogenase/reductase (SDR family) member 2 |
| Other Description | dehydrogenase/reductase SDR family member 2, mitochondrial|dehydrogenase/reductase member 2|dicarbonyl reductase HEP27|protein D|short chain dehydrogenase/reductase family 25C member 1|short chain dehydrogenase/reductase family 25C, member 1|short-chain alcohol dehydrogenase family member |
| Swissprots | Q7Z789 Q13268 Q9H2R2 D3DS54 Q53GS4 |
| Accessions | AAG33703 EAW66130 EAW66131 Q13268 AB209653 BAD92890 AK000345 AK092834 AK222857 BAD96577 AK309945 AK309975 BC002786 AAH02786 BC007339 AAH07339 HQ448428 ADQ32908 U31875 AAA82048 XM_005267249 XP_005267306 XM_006720000 XP_006720063 XM_006720001 XP_006720064 XM_006720002 XP_006720065 XM_011536338 XP_011534640 XM_011536339 XP_011534641 XR_943366 XR_943367 NM_005794 NP_005785 NM_182908 NP_878912 |
| Function | Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}. |
| Subcellular Location | Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal. |
| Tissue Specificity | Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269|PubMed:11944995}. |