DHRS2

Gene Symbol	DHRS2
Entrez Gene	10202
Alt Symbol	HEP27, SDR25C1
Species	Human
Gene Type	protein-coding
Description	dehydrogenase/reductase (SDR family) member 2
Other Description	dehydrogenase/reductase SDR family member 2, mitochondrial|dehydrogenase/reductase member 2|dicarbonyl reductase HEP27|protein D|short chain dehydrogenase/reductase family 25C member 1|short chain dehydrogenase/reductase family 25C, member 1|short-chain alcohol dehydrogenase family member
Swissprots	Q7Z789 Q13268 Q9H2R2 D3DS54 Q53GS4
Accessions	AAG33703 EAW66130 EAW66131 Q13268 AB209653 BAD92890 AK000345 AK092834 AK222857 BAD96577 AK309945 AK309975 BC002786 AAH02786 BC007339 AAH07339 HQ448428 ADQ32908 U31875 AAA82048 XM_005267249 XP_005267306 XM_006720000 XP_006720063 XM_006720001 XP_006720064 XM_006720002 XP_006720065 XM_011536338 XP_011534640 XM_011536339 XP_011534641 XR_943366 XR_943367 NM_005794 NP_005785 NM_182908 NP_878912
Function	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}.
Subcellular Location	Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Tissue Specificity	Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269|PubMed:11944995}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DHRS2 full length protein - ab160873 from Abcam Category Protein Source Wheat germ Species Human

Human DHRS2 protein fragment - ab160874 from Abcam Category Protein Source Wheat germ Species Human

DHRS2 / HEP27 Antibody Blocking Peptide - LS-E7820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DHRS2 / HEP27 Antibody Blocking Peptide - LS-E15551 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DHRS2 / HEP27 Antibody Blocking Peptide - LS-E15550 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DHRS2 Protein - H00010202-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DHRS2 Protein - H00010202-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DHRS2-Antibody-C-term-Blocking-peptide - BP5339b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DHRS2 Blocking Peptide - 33R-3324 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DHRS2 Blocking Peptide - 33R-4902 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DHRS2 Blocking Peptide - abx063657 from Abbexa Category Peptide Species Human, Mouse, Rat

DHRS2 - H00010202-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

DHRS2 - H00010202-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

DHRS2 - H00010202-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

DHRS2 - H00010202-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DHRS2 - H00010202-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DHRS2 fusion protein - Ag8364 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DHRS2 fusion protein - ag8508 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DHRS2, His-tagged - DHRS2-11974H from Creative Biomart Category Protein Source E.coli Species Human

DHRS2 Blocking Peptide - CBP2463 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

DHRS2 Peptide - BS5698P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Dehydrogenase/reductase SDR family member 2(DHRS2) - CSB-YP615674HU CSB-EP615674HU CSB-BP615674HU CSB-MP615674HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DHRS2 Recombinant Protein Antigen - NBP2-49605PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

DHRS2 Peptide, Human - M34GP04274H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human DHRS2 protein - orb54247 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

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