DHRS2

Gene Symbol	DHRS2
Entrez Gene	10202
Alt Symbol	HEP27, SDR25C1
Species	Human
Gene Type	protein-coding
Description	dehydrogenase/reductase (SDR family) member 2
Other Description	dehydrogenase/reductase SDR family member 2, mitochondrial|dehydrogenase/reductase member 2|dicarbonyl reductase HEP27|protein D|short chain dehydrogenase/reductase family 25C member 1|short chain dehydrogenase/reductase family 25C, member 1|short-chain alcohol dehydrogenase family member
Swissprots	Q7Z789 Q13268 Q9H2R2 D3DS54 Q53GS4
Accessions	AAG33703 EAW66130 EAW66131 Q13268 AB209653 BAD92890 AK000345 AK092834 AK222857 BAD96577 AK309945 AK309975 BC002786 AAH02786 BC007339 AAH07339 HQ448428 ADQ32908 U31875 AAA82048 XM_005267249 XP_005267306 XM_006720000 XP_006720063 XM_006720001 XP_006720064 XM_006720002 XP_006720065 XM_011536338 XP_011534640 XM_011536339 XP_011534641 XR_943366 XR_943367 NM_005794 NP_005785 NM_182908 NP_878912
Function	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}.
Subcellular Location	Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Tissue Specificity	Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269|PubMed:11944995}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DHRS2 (K-14) - sc-104879 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DHRS2 (H-74) - sc-292128 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DHRS2 (G-12) - sc-104878 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DHRS2 (L-13) - sc-104880 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DHRS2 antibody - ab83254 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 antibody - ab194801 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 antibody - ab77107 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DHRS2 antibody - ab103943 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 antibody - ab136096 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, AP) - LS-C256079 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, APC) - LS-C256081 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, Biotin) - LS-C256082 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, FITC) - LS-C256083 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, Azide-free, HRP) - LS-C256084 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235, PE) - LS-C256086 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa229-300) - LS-C307243 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DHRS2 / HEP27 Antibody (aa97-146) - LS-C291877 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa27-76) - LS-C117051 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa156-201) - LS-C313740 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa108-157) - LS-C101952 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa205-235) - LS-C329467 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa111-160) - LS-C119898 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody (aa197-225) - LS-C167395 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DHRS2 / HEP27 Antibody - LS-C334724 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DHRS2 Antibody - NBP1-54922 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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