PKD1

Gene Symbol	PKD1
Entrez Gene	5310
Alt Symbol	PBP, Pc-1, TRPP1
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 1 (autosomal dominant)
Other Description	autosomal dominant polycystic kidney disease 1 protein|polycystic kidney disease-associated protein|polycystin 1|polycystin-1|transient receptor potential cation channel, subfamily P, member 1
Swissprots	Q15141 Q15140 P98161
Accessions	AAB59488 AAC34211 AAC41765 ACN97591 ACN97592 ACN97593 AIT52087 AJP06022 EAW85553 EAW85554 EAW85555 P98161 AB209025 BAD92262 AB209675 BAD92912 AK309422 CN268814 L33243 AAC37576 U24497 AAC50128 XM_005255370 XP_005255427 XM_011522525 XP_011520827 XM_011522526 XP_011520828 XM_011522527 XP_011520829 XM_011522528 XP_011520830 XM_011522529 XP_011520831 XM_011522530 XP_011520832 XM_011522531 XP_011520833 XM_011522532 XP_011520834 XM_011522533 XP_011520835 XM_011522534 XP_011520836 XM_011522535 XP_011520837 XM_011522536 XP_011520838 XM_011522537 XP_011520839 XR_932867 XR_932868 XR_932869 XR_932870 NM_000296 NP_000287 NM_001009944 NP_001009944
Function	Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein- carbohydrate interactions. {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949}.
Subcellular Location	Membrane {ECO:0000269|PubMed:20980620}; Multi-pass membrane protein {ECO:0000269|PubMed:20980620}. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). {ECO:0000250|UniProtKB:O08852}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Polycystin-1 (7E12) - sc-130554 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Polyclonal

Polycystin-1 (C-20) - sc-10372 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-1 (A-20) - sc-10371 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-1 (H-260) - sc-25570 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Polycystin-1 (P-15) - sc-10370 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Polycystin 1 (phospho S738) antibody - ab138391 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Polycystin 1 antibody - ab72472 from Abcam Host Rabbit Clonality Polyclonal

Anti-Polycystin 1 antibody - ab203240 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Polycystin 1 antibody - ab72473 from Abcam Host Rabbit Clonality Polyclonal

Anti-PKD1 / Polycystin Antibody (aa2281-2292) - LS-C139802 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PKD1 / Polycystin Antibody (aa4289-4300) IHC-plus™ - LS-B3847 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

Polycystin-1/PKD1 Antibody - NBP1-20031 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Polycystin-1/PKD1 Antibody [Unconjugated] - AF6270 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

Polycystin-1/PKD1 Antibody - NBP1-19940 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Polycystin-1/PKD1 Antibody - NBP1-19424 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Polycystin-1/PKD1 Antibody - NB100-92213 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Polycystin-1/PKD1 [p Ser738] Antibody - NBP1-19939 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Polycystin-1/PKD1 Antibody - NB100-98745 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Polycystin 1 Polyclonal Antibody - bs-2157R from Bioss Prices $279.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

PKD1-aa2281-2292-Antibody-C-Term - AF3578a from Abgent, a WuXi AppTec company Prices $325.00 Sizes 100 µg Host Goat Clonality Polyclonal

Human Polycystin-1/PKD1 Antibody - AF6270 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep

Human Polycystin-1/PKD1 Affinity Purified Polyclonal Ab, Sheep IgG - AF6270-SP from R&D Systems Host Sheep Clonality Polyclonal

PKD1 Antibody (Phospho-Ser738) (OAAF05452) - OAAF05452 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PKD1/PKC-mu Antibody (OAAF05918) - OAAF05918 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PkD1/PkCmicro (Phospho-Tyr463) antibody - orb106252 from Biorbyt Prices $238.00, $323.00 Sizes 50 μl, 100 μg Host Rabbit Clonality Polyclonal

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