PKD1

Gene Symbol PKD1
Entrez Gene 5310
Alt Symbol PBP, Pc-1, TRPP1
Species Human
Gene Type protein-coding
Description polycystic kidney disease 1 (autosomal dominant)
Other Description autosomal dominant polycystic kidney disease 1 protein|polycystic kidney disease-associated protein|polycystin 1|polycystin-1|transient receptor potential cation channel, subfamily P, member 1
Swissprots Q15141 Q15140 P98161
Accessions AAB59488 AAC34211 AAC41765 ACN97591 ACN97592 ACN97593 AIT52087 AJP06022 EAW85553 EAW85554 EAW85555 P98161 AB209025 BAD92262 AB209675 BAD92912 AK309422 CN268814 L33243 AAC37576 U24497 AAC50128 XM_005255370 XP_005255427 XM_011522525 XP_011520827 XM_011522526 XP_011520828 XM_011522527 XP_011520829 XM_011522528 XP_011520830 XM_011522529 XP_011520831 XM_011522530 XP_011520832 XM_011522531 XP_011520833 XM_011522532 XP_011520834 XM_011522533 XP_011520835 XM_011522534 XP_011520836 XM_011522535 XP_011520837 XM_011522536 XP_011520838 XM_011522537 XP_011520839 XR_932867 XR_932868 XR_932869 XR_932870 NM_000296 NP_000287 NM_001009944 NP_001009944
Function Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein- carbohydrate interactions. {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949}.
Subcellular Location Membrane {ECO:0000269|PubMed:20980620}; Multi-pass membrane protein {ECO:0000269|PubMed:20980620}. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). {ECO:0000250|UniProtKB:O08852}.

Polycystin-1 CRISPR/Cas9 KO Plasmid (h) - sc-400983 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 HDR Plasmid (h) - sc-400983-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 Double Nickase Plasmid (h) - sc-400983-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 Double Nickase Plasmid (h2) - sc-400983-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 CRISPR Activation Plasmid (h) - sc-400983-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 CRISPR Activation Plasmid (h2) - sc-400983-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 Lentiviral Activation Particles (h) - sc-400983-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 Lentiviral Activation Particles (h2) - sc-400983-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 siRNA (h) - sc-40861 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Polycystin-1 shRNA Plasmid (h) - sc-40861-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Polycystin-1 shRNA (h) Lentiviral Particles - sc-40861-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU067831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16853 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16853 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PKD1 siRNA (Human) - CRH3552 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Polycystin-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400983-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-1 HDR Plasmid (h2) - sc-400983-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human PKD1 siRNA - orb264054 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PKD1 shRNA Plasmid (Human) - CHH3552 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PKD1 miRNA 3'UTR clone - MiUTR3H-04056 from Creative biogene

Species Reactivities Human

PKD1 miRNA 3'UTR clone - MiUTR3H-04057 from Creative biogene

Species Reactivities Human
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