PKD1

Gene Symbol	PKD1
Entrez Gene	5310
Alt Symbol	PBP, Pc-1, TRPP1
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 1 (autosomal dominant)
Other Description	autosomal dominant polycystic kidney disease 1 protein|polycystic kidney disease-associated protein|polycystin 1|polycystin-1|transient receptor potential cation channel, subfamily P, member 1
Swissprots	Q15141 Q15140 P98161
Accessions	AAB59488 AAC34211 AAC41765 ACN97591 ACN97592 ACN97593 AIT52087 AJP06022 EAW85553 EAW85554 EAW85555 P98161 AB209025 BAD92262 AB209675 BAD92912 AK309422 CN268814 L33243 AAC37576 U24497 AAC50128 XM_005255370 XP_005255427 XM_011522525 XP_011520827 XM_011522526 XP_011520828 XM_011522527 XP_011520829 XM_011522528 XP_011520830 XM_011522529 XP_011520831 XM_011522530 XP_011520832 XM_011522531 XP_011520833 XM_011522532 XP_011520834 XM_011522533 XP_011520835 XM_011522534 XP_011520836 XM_011522535 XP_011520837 XM_011522536 XP_011520838 XM_011522537 XP_011520839 XR_932867 XR_932868 XR_932869 XR_932870 NM_000296 NP_000287 NM_001009944 NP_001009944
Function	Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein- carbohydrate interactions. {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949}.
Subcellular Location	Membrane {ECO:0000269|PubMed:20980620}; Multi-pass membrane protein {ECO:0000269|PubMed:20980620}. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). {ECO:0000250|UniProtKB:O08852}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Polycystin-1, PKD1, Human, ELISA Kit - E9813h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Human PKD1 ELISA Kit - HP0120 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PKD1 ELISA Kit - AP0120 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Human PKD1(Protein Kinase D1) ELISA Kit - E-EL-H1185 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

PKD1, ELISA Kit - MBS2513875 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

polycystic kidney disease 1 (autosomal dominant) , ELISA Kit - MBS900423 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Human Polycystin-1(PKD1) ELISA kit - CSB-EL018051HU from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Mouse PKD1 / Polycystin ELISA Kit (Custom ELISA) - LS-F20569 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Polycystin-1, ELISA Kit - MBS282198 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PKD1(Protein Kinase D1) ELISA Kit - E-EL-H1185 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.94 ng/mLng/mL Range 1.56~100 ng/mL

Human Polycystin-1 ELISA Kit - abx251885 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human PKD1 / Polycystin ELISA Kit (Sandwich ELISA) - LS-F13397 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

PKD1/2/3 ELISA Kit - DEIA-XYA1468 from Creative Diagnostics Category ELISA Kit

PKD1/PKC mu ELISA Kit - DEIA-XYA1470 from Creative Diagnostics Category ELISA Kit

PKD1/2/3 (Phospho-Ser738+Ser742) ELISA Kit - DEIA-XYA1469 from Creative Diagnostics Category ELISA Kit

PKD1/PKC mu (Phospho-Ser205) ELISA Kit - DEIA-XYA1471 from Creative Diagnostics Category ELISA Kit

PKD1/PKC mu (Phospho-Tyr463) ELISA Kit - DEIA-XYA1472 from Creative Diagnostics Category ELISA Kit

Human Polycystin-1 (PKD1) ELISA Kit - EKC35070 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Human Polycystin-1 ELISA Kit - EKE55468 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.11 ng/mL Range 0.156-10 ng/mL

PKD1 - EKH5028 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

PKD1 ELISA Kit (Human) : 96 Wells (OKEH02015) - OKEH02015 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.11 ng/mL Range 0.156 - 10 ng/mL

Human PKD1 ELISA Kit - E030070 from Biobool Category ELISA Kit Sensitivity 7.81 pg/ml

Human PKD1 ELISA Kit - EHP0120 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Human Polycystin-1 ELISA Kit - EK5046 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 23pg/mL Range 31.2-2000 pg/mL

Polycystin-1, ELISA Kit - MBS2885674 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

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