| Gene Symbol | FZD1 |
|---|---|
| Entrez Gene | 8321 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 1 |
| Other Description | Wnt receptor|frizzled 1, seven transmembrane spanning receptor|frizzled family receptor 1|frizzled homolog 1|frizzled, Drosophila, homolog of, 1|frizzled-1|fz-1|fzE1|hFz1 |
| Swissprots | O94815 A4D1E8 Q9UP38 Q549T8 |
| Accessions | AAS02008 EAL24161 EAW76871 Q9UP38 AB017363 BAA34666 AF072872 AAD41636 AK314996 BAG37492 AL049994 BC017719 BC051271 AAH51271 NM_003505 NP_003496 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |