FZD1

Gene Symbol	FZD1
Entrez Gene	8321
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 1
Other Description	Wnt receptor|frizzled 1, seven transmembrane spanning receptor|frizzled family receptor 1|frizzled homolog 1|frizzled, Drosophila, homolog of, 1|frizzled-1|fz-1|fzE1|hFz1
Swissprots	O94815 A4D1E8 Q9UP38 Q549T8
Accessions	AAS02008 EAL24161 EAW76871 Q9UP38 AB017363 BAA34666 AF072872 AAD41636 AK314996 BAG37492 AL049994 BC017719 BC051271 AAH51271 NM_003505 NP_003496
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled homolog 1 protein fragment - ab198659 from Abcam Category Protein Source HEK 293 cells Species Human

FZD1 / Frizzled 1 Antibody Blocking Peptide - LS-E7076 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD1 / Frizzled 1 Antibody Blocking Peptide - LS-E7077 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD1 / Frizzled 1 Antibody Blocking Peptide - LS-E28763 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD1 / Frizzled 1 Antibody Blocking Peptide - LS-E28901 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Frizzled-1 Peptide - P1247 from Novus Biologicals Category Peptide Species Human

Frizzled-1 Peptide - P1246 from Novus Biologicals Category Peptide Species Human

FZD1-Antibody-Center-Blocking-Peptide - BP2755c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FZD1-Antibody-C-term-Blocking-Peptide - BP2755b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Frizzled-1 Fc Chimera, CF - 5988-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

FZD1 Protein (OPPA00205) - OPPA00205 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source HEK293 (Human Embryonic Kidney cell line).

Human Frizzled Homolog 1 Protein - abx066693 from Abbexa Category Protein Source E.coli Species Human

QKI, Human Recombinant - 228-13257-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Frizzled-1 - 228-13257-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source HEK293 (Human Embryonic Kidney cell line). Species Human

Recombinant Human Frizzled-1 - 228-13257-3 from RayBiotech Category Protein Prices $5,203.00 Sizes 3 µg Source HEK293 (Human Embryonic Kidney cell line). Species Human

Frizzled Homolog 1 (FZD1), Human - 20-8942 from ARP American Research Products Category Protein Prices $379.00 Sizes 50 µg Source E.coli Species Human

FZD1 fusion protein - ag10406 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FZD1 Human - PRPS-823 from NeoScientific Category Protein Prices $65.00, $169.00, $1,430.00 Sizes 2 µg, 10 µg, 100 µg Source HEK293 (Human Embryonic Kidney cell line). Species Human

Recombinant Human Frizzled-1 Protein - BP002864-PRO-816 from Syd Labs Category Protein Prices $160.00, $1,100.00 Sizes 10 µg, 100 µg Source HEK293 (Human Embryonic Kidney cell line)-derived. Species Human

FZD1 Human Protein - GWB-BSP486 from Genway Biotech Category Protein Prices $75.00, $165.00, $1,315.00 Sizes 2 μg, 10 μg, 100 μg Source HEK293 (Human Embryonic Kidney cell line). Species Human

FZD1 - NKX-452 from Reagent Proteins Category Protein Prices $364.00, $1,316.00 Sizes 10.00 µg, 100.00 µg Source HEK293 (Human Embryonic Kidney cell line).

Recombinant Frizzled Homolog 1 (FZD1) - RPE571Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Frizzled Homolog 1 (FZD1) - RPE571Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Frizzled-1 (L55) Peptide - BS2600P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Frizzled-1 (Q54) Peptide - BS2714P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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