FZD1
| Gene Symbol | FZD1 |
|---|---|
| Entrez Gene | 8321 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 1 |
| Other Description | Wnt receptor|frizzled 1, seven transmembrane spanning receptor|frizzled family receptor 1|frizzled homolog 1|frizzled, Drosophila, homolog of, 1|frizzled-1|fz-1|fzE1|hFz1 |
| Swissprots | O94815 A4D1E8 Q9UP38 Q549T8 |
| Accessions | AAS02008 EAL24161 EAW76871 Q9UP38 AB017363 BAA34666 AF072872 AAD41636 AK314996 BAG37492 AL049994 BC017719 BC051271 AAH51271 NM_003505 NP_003496 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-1 CRISPR/Cas9 KO Plasmid (h) - sc-401365 from Santa Cruz Biotechnology
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frizzled-1 HDR Plasmid (h) - sc-401365-HDR from Santa Cruz Biotechnology
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frizzled-1 Double Nickase Plasmid (h) - sc-401365-NIC from Santa Cruz Biotechnology
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frizzled-1 Double Nickase Plasmid (h2) - sc-401365-NIC-2 from Santa Cruz Biotechnology
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frizzled-1 CRISPR Activation Plasmid (h) - sc-401365-ACT from Santa Cruz Biotechnology
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frizzled-1 CRISPR Activation Plasmid (h2) - sc-401365-ACT-2 from Santa Cruz Biotechnology
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frizzled-1 Lentiviral Activation Particles (h) - sc-401365-LAC from Santa Cruz Biotechnology
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frizzled-1 Lentiviral Activation Particles (h2) - sc-401365-LAC-2 from Santa Cruz Biotechnology
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frizzled-1 siRNA (h) - sc-39977 from Santa Cruz Biotechnology
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frizzled-1 shRNA Plasmid (h) - sc-39977-SH from Santa Cruz Biotechnology
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frizzled-1 shRNA (h) Lentiviral Particles - sc-39977-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9022 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9022 from Sigma-Aldrich
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FZD1 siRNA (Human) - CRH5443 from Cohesion Biosciences
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Frizzled-1 RNAi - H00008321-R02 from Novus Biologicals
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FZD1 - MBS8227479 from MyBioSource
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shRNA set against Human FZD1 (NM_003505.1) - SHH298053 from Creative biogene
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shRNA set against Human FZD1(NM_003505.1) - SHH071939 from Creative biogene
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FZD1 shRNA Plasmid (Human) - CHH5443 from Cohesion Biosciences
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FZD1 miRNA 3'UTR clone - MiUTR1H-03889 from Creative biogene
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