| Gene Symbol |
DUSP23
|
| Entrez Gene |
54935
|
| Alt Symbol |
DUSP25, LDP-3, MOSP, VHZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual specificity phosphatase 23
|
| Other Description |
VH1-like member Z|VH1-like phosphatase Z|dual specificity protein phosphatase 23|low molecular mass dual specificity phosphatase 3|low-molecular-mass dual-specificity phosphatase 3
|
| Swissprots |
Q9NX48 Q9BVJ7
|
| Accessions |
CAD44455 EAW52775 Q9BVJ7 AB164404 BAD12141 AF086553 AK000449 BAA91172 BC001140 AAH01140 JF432846 ADZ16063 XM_005245289 XP_005245346 NM_017823 NP_060293
|
| Function |
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
|
| Tissue Specificity |
Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach. {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}.
|