Gene Symbol | DUSP23 |
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Entrez Gene | 54935 |
Alt Symbol | DUSP25, LDP-3, MOSP, VHZ |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 23 |
Other Description | VH1-like member Z|VH1-like phosphatase Z|dual specificity protein phosphatase 23|low molecular mass dual specificity phosphatase 3|low-molecular-mass dual-specificity phosphatase 3 |
Swissprots | Q9NX48 Q9BVJ7 |
Accessions | CAD44455 EAW52775 Q9BVJ7 AB164404 BAD12141 AF086553 AK000449 BAA91172 BC001140 AAH01140 JF432846 ADZ16063 XM_005245289 XP_005245346 NM_017823 NP_060293 |
Function | Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}. |
Subcellular Location | Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear. |
Tissue Specificity | Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach. {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}. |
DUSP23 CRISPR/Cas9 KO Plasmid (h) - sc-412388 from Santa Cruz Biotechnology
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DUSP23 HDR Plasmid (h) - sc-412388-HDR from Santa Cruz Biotechnology
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DUSP23 Double Nickase Plasmid (h) - sc-412388-NIC from Santa Cruz Biotechnology
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DUSP23 Double Nickase Plasmid (h2) - sc-412388-NIC-2 from Santa Cruz Biotechnology
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DUSP23 CRISPR Activation Plasmid (h) - sc-412388-ACT from Santa Cruz Biotechnology
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DUSP23 CRISPR Activation Plasmid (h2) - sc-412388-ACT-2 from Santa Cruz Biotechnology
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DUSP23 Lentiviral Activation Particles (h) - sc-412388-LAC from Santa Cruz Biotechnology
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DUSP23 Lentiviral Activation Particles (h2) - sc-412388-LAC-2 from Santa Cruz Biotechnology
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DUSP23 siRNA (h) - sc-77202 from Santa Cruz Biotechnology
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DUSP23 shRNA Plasmid (h) - sc-77202-SH from Santa Cruz Biotechnology
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DUSP23 shRNA (h) Lentiviral Particles - sc-77202-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU129511 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0127 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0129 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0128 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7553 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7553 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01402 from Sigma-Aldrich
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DUSP23 siRNA (Human) - CRJ0338 from Cohesion Biosciences
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DUSP23 - MBS8224829 from MyBioSource
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shRNA set against Human DUSP23 (NM_017823.3) - SHH281817 from Creative biogene
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shRNA set against Human DUSP23(NM_017823.3) - SHH019145 from Creative biogene
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Human DUSP23 siRNA - orb270839 from Biorbyt
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DUSP23 shRNA Plasmid (Human) - CHJ0338 from Cohesion Biosciences
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DUSP23 miRNA 3'UTR clone - MiUTR1H-03036 from Creative biogene
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