SH3BP5

Gene Symbol SH3BP5
Entrez Gene 9467
Alt Symbol SAB, SH3BP-5
Species Human
Gene Type protein-coding
Description SH3-domain binding protein 5 (BTK-associated)
Other Description SH3 domain-binding protein 5|SH3 domain-binding protein that preferentially associates with BTK
Swissprots Q5JWV9 B3KQW6 O60239
Accessions EAW64225 EAW64226 EAW64227 EAW64228 O60239 AA843106 AB005047 BAA25922 AK090524 BAG52178 AK313167 BAG35985 AL117422 CAI46220 AW673562 BC006169 BC010123 AAH10123 BC023195 BG475051 BP308415 BX114836 BX641159 CAE46071 CA429664 CN402267 DA530463 DQ892875 ABM83801 EU176725 ABW03526 XM_011534251 XP_011532553 XM_011534252 XP_011532554 XM_011534253 XP_011532555 XM_011534254 XP_011532556 NM_001018009 NP_001018009 NM_004844 NP_004835
Function Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:9571151}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:12167088}.
Tissue Specificity Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. {ECO:0000269|PubMed:9571151}.

Sab (A-3) - sc-390512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sab (A-3): sc-390512. Western blot analysis of Sab expression in non-transfected: sc-117752 (A) and human Sab transfected: sc-171068 (B) 293T whole cell lysates.

Sab (E-18) - sc-10167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sab (E-18): sc-10167. Western blot analysis of Sab expression in Raji (A), A-431 (B), K-562 (C), F9 (D) and OVCAR-3 (E) whole cell lysates.

Sab (T-17) - sc-10166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sab (T-17): sc-10166. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of glandular cells.

Sab (H-113) - sc-292762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Sab (H-113): sc-292762. Western blot analysis of Sab expression in non-transfected: sc-117752 (A) and human Sab transfected: sc-171068 (B) 293T whole cell lysates.

Sab (PL-A23) - sc-135617 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Sab (PL-A23): sc-135617. Western blot analysis of Sab expression in non-transfected 293T: sc-117752 (A), human Sab transfected 293T: sc-171068 (B) and Raji (C) whole cell lysates.

Anti-SH3BP5 antibody - ab56603 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab56603 stained HeLa cells. The cells were 4% formaldehyde fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab56603, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-SH3BP5 antibody - ab126231 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SH3BP5 antibody (ab126231) at 1/1000 dilution + THP1 whole cell lysate at 30 µg

Anti-SH3BP5 antibody - ab126125 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SH3BP5 antibody (ab126125) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-SH3BP5 / SAB Antibody (N-Terminus) - LS-C135782 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SH3BP5 antibody LS-C135782 Western blot of HCT15 Cell lysate. Antibody concentration 1 ug/ml.

Anti-SH3BP5 / SAB Antibody (aa215-264) - LS-C135781 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SH3BP5 antibody LS-C135781 Western blot of Fetal Liver lysate.

Anti-SH3BP5 / SAB Antibody (aa4-113, Azide-free) - LS-C330653 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SH3BP5 / SAB Antibody - LS-C155326 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Colon carcinoma, using SH3BP5 antibody at 1:250 dilution.

Anti-SH3BP5 / SAB Antibody - LS-C155403 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE SH3BP5 antibody diluted at 1:1000

Anti-SH3BP5 / SAB Antibody (clone 2B3) IHC-plus™ - LS-B4485 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Anti-SH3BP5 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4485 concentration 5 ug/ml.

SH3BP5 Antibody (2B3) - H00009467-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Western Blot: SH3BP5 Antibody (2B3) [H00009467-M01] - SH3BP5 monoclonal antibody (M01), clone 2B3 Analysis of SH3BP5 expression in A-431.

SH3BP5 Antibody - NBP1-80796 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SH3BP5 Antibody - NBP2-20343 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH3BP5 Antibody [NBP2-20343] - Sample (30 ug of whole cell lysate) A: THP-1 12% SDS PAGE gel, diluted at 1:1000.

SH3BP5 Antibody - NBP2-20344 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH3BP5 Antibody [NBP2-20344] - Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE gel, diluted at 1:1000.

SH3BP5 Antibody - H00009467-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Anti-SH3BP5 antibody produced in rabbit - HPA036445 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SH3BP5: <B>Cat. No. HPA036445</B>: Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in subsets of cells in seminiferus ducts.

Monoclonal Anti-SH3BP5 antibody produced in mouse - SAB1404723 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D5
<B>Immunoblotting</B><BR/>Monoclonal Anti-SH3BP5: <B>Cat. No. SAB1404723</B>: Antibody concentration: 1 μg/mL. Specific band of ~38.1 kDa using immunogen protein lysate.

Monoclonal Anti-SH3BP5 antibody produced in mouse - WH0009467M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
<B>Immunoblotting</B><BR/>Monoclonal Anti-SH3BP5, <B>Cat. No. WH0009467M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~47 kDa using A-431 lysate.

SH3BP5 Antibody (OALA04213) - OALA04213 from Aviva Systems Biology

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone [clone 2B3]

SH3BP5 antibody - C-terminal region (ARP60361_P050) - ARP60361_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SH3BP5 antibody - N-terminal region (ARP60362_P050) - ARP60362_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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