| Gene Symbol |
SH3BP5
|
| Entrez Gene |
9467
|
| Alt Symbol |
SAB, SH3BP-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3-domain binding protein 5 (BTK-associated)
|
| Other Description |
SH3 domain-binding protein 5|SH3 domain-binding protein that preferentially associates with BTK
|
| Swissprots |
Q5JWV9 B3KQW6 O60239
|
| Accessions |
EAW64225 EAW64226 EAW64227 EAW64228 O60239 AA843106 AB005047 BAA25922 AK090524 BAG52178 AK313167 BAG35985 AL117422 CAI46220 AW673562 BC006169 BC010123 AAH10123 BC023195 BG475051 BP308415 BX114836 BX641159 CAE46071 CA429664 CN402267 DA530463 DQ892875 ABM83801 EU176725 ABW03526 XM_011534251 XP_011532553 XM_011534252 XP_011532554 XM_011534253 XP_011532555 XM_011534254 XP_011532556 NM_001018009 NP_001018009 NM_004844 NP_004835
|
| Function |
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:9571151}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:12167088}.
|
| Tissue Specificity |
Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. {ECO:0000269|PubMed:9571151}.
|