TONSL

Gene Symbol TONSL
Entrez Gene 4796
Alt Symbol IKBR, NFKBIL2
Species Human
Gene Type protein-coding
Description tonsoku-like, DNA repair protein
Other Description I-kappa-B-related protein|NF-kappa-B inhibitor-like protein 2|ikappaBR|inhibitor of kappa B-related protein|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2|tonsoku-like protein
Swissprots C9JNV8 Q9UGJ2 C9JKB1 B5MDP0 Q13006 Q96HA7
Accessions CAB63467 CDI30207 EAW82092 EAW82093 Q96HA7 AB209126 BAD92363 AK097406 BC008782 AAH08782 BF475381 CN366457 DQ892694 ABM83620 DQ895937 ABM86863 XM_011517047 XP_011515349 XM_011517048 XP_011515350 XM_011517049 XP_011515351 XM_011517050 XP_011515352 NM_013432 NP_038460
Function Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:7738005}.
Subcellular Location Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Tissue Specificity Expressed in heart, skeletal muscle and tracheal epithelial cells. {ECO:0000269|PubMed:7738005}.

NFKBIL2 (V-17) - sc-98037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NFKBIL2 antibody - ab67577 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NFKBIL2 antibody (ab67577) at 1/500 dilutionLane 1 : NFKBIL2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutionObserved band size : 200 kDa (why is the actual band size different from the predicted?)Additional bands at : 100 kDa. We are unsure as to the identity of these extra bands.

Anti-NFKBIL2 antibody - ab83778 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NFKBIL2 antibody (ab83778) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-NFKBIL2 antibody [GT648] - N-terminal - ab184626 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT648
All lanes : Anti-NFKBIL2 antibody [GT648] - N-terminal (ab184626) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-NFKBIL2 antibody - N-terminal - ab154621 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFKBIL2 antibody - N-terminal (ab154621) at 1/1000 dilutionLane 1 : H1299 whole cell lysate/extractLane 2 : HCT116 whole cell lysate/extractLane 3 : MCF7 whole cell lysate/extractLysates/proteins at 30 µg per lane.

Anti-TONSL Antibody (aa351-400) - LS-C102858 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TONSL / NFKBIL2 antibody LS-C102858 Western blot of 293T cell lysate.

Anti-TONSL Antibody (C-Terminus) - LS-C345827 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TONSL Antibody with human 293T Whole Cell lysate.

Anti-TONSL Antibody (aa38-65) - LS-C158382 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NFKBIL2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The NFKBIL2 antibody detected the NFKBIL2 protein (arrow).

Anti-TONSL Antibody (aa425-475) - LS-C290492 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human NFKBIL2 by Western Blot. Samples: Whole cell lysate from 293T (15 and 50 ug), HeLa (H; 50 ug), and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-NFKBIL2 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-TONSL Antibody (aa38-65, APC) - LS-C223461 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65, AP) - LS-C223460 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65, FITC) - LS-C223462 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65, Azide-free, HRP) - LS-C223463 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65, Biotin) - LS-C223464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65, PE) - LS-C223465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TONSL Antibody (aa38-65) - LS-C323323 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

NFKBIL2 Antibody - NBP1-87764 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: NFKBIL2 Antibody [NBP1-87764] Staining of human cell line U-251 MG shows positivity in nucleus but not nucleoli.

NFKBIL2 Antibody - NBP2-19530 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: NFKBIL2 Antibody [NBP2-19530] - Sample (30 ug of whole cell lysate) A: Jurkat 5% SDS PAGE gel, diluted at 1:1000.

NFKBIL2 Antibody - NBP2-19531 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NFKBIL2 Antibody [NBP2-19531] - NFKBIL2 antibody [N1N2], N-term detects NFKBIL2 protein by Western blot analysis. A. 30 ug H1299 whole cell lysate/extractB. 30 ug HCT116 whole cell lysate/extractC. 30 ug MCF-7 whole cell lysate/extract5 % SDS-PAGENFKBIL2 antibody [N1N2], N-term dilution

NFKBIL2 Antibody - H00004796-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: NFKBIL2 Antibody [H00004796-B01P] - analysis of NFKBIL2 expression in transfected 293T cell line by NFKBIL2 MaxPab polyclonal antibody. Lane 1: NFKBIL2 transfected lysate (134.09 KDa). Lane 2: Non-transfected lysate.

NFKBIL2 Antibody - H00004796-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

NFKBIL2 Antibody - H00004796-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TONSL antibody produced in rabbit - HPA024679 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NFKBIL2: <B>Cat. No. HPA024679</B>: Immunohistochemical staining of human skeletal muscle shows moderate cytoplasmic positivity.

Anti-NFKBIL2 antibody produced in rabbit - SAB1410838 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NFKBIL2: <B>Cat. No. SAB1410838</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~132.9 kDa using NFKBIL2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-TONSL antibody produced in rabbit - SAB4301141 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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