TONSL

Gene Symbol TONSL
Entrez Gene 4796
Alt Symbol IKBR, NFKBIL2
Species Human
Gene Type protein-coding
Description tonsoku-like, DNA repair protein
Other Description I-kappa-B-related protein|NF-kappa-B inhibitor-like protein 2|ikappaBR|inhibitor of kappa B-related protein|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2|tonsoku-like protein
Swissprots C9JNV8 Q9UGJ2 C9JKB1 B5MDP0 Q13006 Q96HA7
Accessions CAB63467 CDI30207 EAW82092 EAW82093 Q96HA7 AB209126 BAD92363 AK097406 BC008782 AAH08782 BF475381 CN366457 DQ892694 ABM83620 DQ895937 ABM86863 XM_011517047 XP_011515349 XM_011517048 XP_011515350 XM_011517049 XP_011515351 XM_011517050 XP_011515352 NM_013432 NP_038460
Function Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:7738005}.
Subcellular Location Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Tissue Specificity Expressed in heart, skeletal muscle and tracheal epithelial cells. {ECO:0000269|PubMed:7738005}.

NFKBIL2 CRISPR/Cas9 KO Plasmid (h) - sc-410906 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 HDR Plasmid (h) - sc-410906-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 Double Nickase Plasmid (h) - sc-410906-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 Double Nickase Plasmid (h2) - sc-410906-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 CRISPR Activation Plasmid (h) - sc-410906-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 CRISPR Activation Plasmid (h2) - sc-410906-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 Lentiviral Activation Particles (h) - sc-410906-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 Lentiviral Activation Particles (h2) - sc-410906-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 siRNA (h) - sc-77827 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NFKBIL2 shRNA Plasmid (h) - sc-77827-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NFKBIL2 shRNA (h) Lentiviral Particles - sc-77827-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU139831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21822 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21822 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02513 from Sigma-Aldrich

Category miRNA

TONSL siRNA (Human) - CRH3183 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NFKBIL2 RNAi - H00004796-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TONSL - MBS8201006 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NFKBIL2 CRISPR/Cas9 KO Plasmid (h2) - sc-410906-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFKBIL2 HDR Plasmid (h2) - sc-410906-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human TONSL (NM_013432.4) - SHH432828 from Creative biogene

Category siRNA
Species Reactivities Human

Human TONSL siRNA - orb263685 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TONSL shRNA Plasmid (Human) - CHH3183 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TONSL miRNA 3'UTR clone - MiUTR3H-06900 from Creative biogene

Species Reactivities Human
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