| Gene Symbol |
TONSL
|
| Entrez Gene |
4796
|
| Alt Symbol |
IKBR, NFKBIL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tonsoku-like, DNA repair protein
|
| Other Description |
I-kappa-B-related protein|NF-kappa-B inhibitor-like protein 2|ikappaBR|inhibitor of kappa B-related protein|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2|tonsoku-like protein
|
| Swissprots |
C9JNV8 Q9UGJ2 C9JKB1 B5MDP0 Q13006 Q96HA7
|
| Accessions |
CAB63467 CDI30207 EAW82092 EAW82093 Q96HA7 AB209126 BAD92363 AK097406 BC008782 AAH08782 BF475381 CN366457 DQ892694 ABM83620 DQ895937 ABM86863 XM_011517047 XP_011515349 XM_011517048 XP_011515350 XM_011517049 XP_011515351 XM_011517050 XP_011515352 NM_013432 NP_038460
|
| Function |
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:7738005}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
|
| Tissue Specificity |
Expressed in heart, skeletal muscle and tracheal epithelial cells. {ECO:0000269|PubMed:7738005}.
|
