Gene Symbol | B3GAT3 |
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Entrez Gene | 26229 |
Alt Symbol | GLCATI, glcUAT-I |
Species | Human |
Gene Type | protein-coding |
Description | beta-1,3-glucuronyltransferase 3 |
Other Description | Sqv-8-like protein|UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase|beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 |
Swissprots | B7ZAB3 Q9UEP0 Q96I06 O94766 |
Accessions | EAW74042 EAW74043 EAW74044 O94766 AB009598 BAA34537 AJ005865 CAA06742 AK075166 AK297970 BAG60280 AK310200 AK316228 BAH14599 BC007906 AAH07906 BC011173 BC019832 AAH19832 BC071961 AAH71961 HQ447823 ADQ32307 XM_011544936 XP_011543238 NM_001288721 NP_001275650 NM_001288722 NP_001275651 NM_001288723 NP_001275652 NM_012200 NP_036332 NR_109991 |
Function | Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP- GlcUA) during completion of linkage region formation. {ECO:0000269|PubMed:24425863}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:21763480}; Single-pass type II membrane protein {ECO:0000269|PubMed:21763480}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:21763480}. |
Tissue Specificity | Ubiquitous (but weakly expressed in all tissues examined). |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
Human B3GAT3 full length protein - ab161932 from Abcam
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Human B3GAT3 protein fragment - ab156962 from Abcam
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Human B3GAT3 protein fragment - ab161933 from Abcam
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B3GAT3 Antibody Blocking Peptide - LS-E1377 from LifeSpan Bioscience
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B3GAT3 Antibody Blocking Peptide - LS-E17049 from LifeSpan Bioscience
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beta-1,3-Glucuronyltransferase 3/B3GAT3 Recombinant Protein - H00026229-P01 from Novus Biologicals
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beta-1,3-Glucuronyltransferase 3/B3GAT3 Partial Recombinant Protein - H00026229-Q01 from Novus Biologicals
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Recombinant Human beta-1,3-Glucuronyltransferase 3/B3GAT3 Protein - NBP2-22712 from Novus Biologicals
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B3GAT3-Antibody-C-term-Blocking-peptide - BP12032b from Abgent, a WuXi AppTec company
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Recombinant Human B3GAT3, CF - 6808-GT-020 from R&D Systems
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B3GAT3 (His Tag) protein - orb171530 from Biorbyt
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Human B3GAT3 protein - orb191419 from Biorbyt
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B3GAT3 Blocking Peptide - 33R-7265 from Fitzgerald
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B3GAT3 protein (His tag) - 80R-2819 from Fitzgerald
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B3GAT3 (29-335, His-tag) - AR50938PU-N from Acris Antibodies
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B3GAT3 (29-335, His-tag) - AR50938PU-S from Acris Antibodies
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B3GAT3 - H00026229-P01-10 from Acris Antibodies
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B3GAT3 - H00026229-P01-25 from Acris Antibodies
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B3GAT3 - H00026229-Q01-10 from Acris Antibodies
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B3GAT3 - H00026229-Q01-25 from Acris Antibodies
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B3GAT3, 29-335aa, Human, His tag, E.coli - 01-P2114 from ARP American Research Products
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B3GAT3 Recombinant Protein - 96-043 from ProSci
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B3GAT3 fusion protein - ag9296 from Proteintech Group
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B3GAT3 fusion protein - Ag8362 from Proteintech Group
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Recombinant Human B3GAT3, His-tagged - B3GAT3-7603H from Creative Biomart
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