| Gene Symbol |
UNC5A
|
| Entrez Gene |
90249
|
| Alt Symbol |
UNC5H1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-5 homolog A (C. elegans)
|
| Other Description |
netrin receptor UNC5A|netrin receptor Unc5h1|protein unc-5 homolog 1|protein unc-5 homolog A|unc-5 homolog 1|unc5 (C.elegans homolog) a
|
| Swissprots |
B2RXE6 Q96GP4 Q8TF26 Q6ZN44
|
| Accessions |
EAW85050 EAW85051 EAW85052 Q6ZN44 AB075856 BAB85562 AK131380 BAD18531 BC009333 AAH09333 BC033727 AAH33727 BC122556 AAI22557 BC157824 AAI57825 BC167811 AAI67811 BI818609 BM712478 XM_006714927 XP_006714990 XM_006714928 XP_006714991 XM_011534686 XP_011532988 XM_011534687 XP_011532989 NM_133369 NP_588610
|
| Function |
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: Unc5a Overexpression Lysate (Adult Normal) [NBL1-17616] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Unc5a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3889_Unc5a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17616-img0002.jpg)