UNC5A

Gene Symbol	UNC5A
Entrez Gene	90249
Alt Symbol	UNC5H1
Species	Human
Gene Type	protein-coding
Description	unc-5 homolog A (C. elegans)
Other Description	netrin receptor UNC5A|netrin receptor Unc5h1|protein unc-5 homolog 1|protein unc-5 homolog A|unc-5 homolog 1|unc5 (C.elegans homolog) a
Swissprots	B2RXE6 Q96GP4 Q8TF26 Q6ZN44
Accessions	EAW85050 EAW85051 EAW85052 Q6ZN44 AB075856 BAB85562 AK131380 BAD18531 BC009333 AAH09333 BC033727 AAH33727 BC122556 AAI22557 BC157824 AAI57825 BC167811 AAI67811 BI818609 BM712478 XM_006714927 XP_006714990 XM_006714928 XP_006714991 XM_011534686 XP_011532988 XM_011534687 XP_011532989 NM_133369 NP_588610
Function	Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. {ECO:0000250}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UNC5H1 CRISPR/Cas9 KO Plasmid (h) - sc-405369 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 HDR Plasmid (h) - sc-405369-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 Double Nickase Plasmid (h) - sc-405369-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 Double Nickase Plasmid (h2) - sc-405369-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 CRISPR Activation Plasmid (h) - sc-405369-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 CRISPR Activation Plasmid (h2) - sc-405369-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 Lentiviral Activation Particles (h) - sc-405369-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 Lentiviral Activation Particles (h2) - sc-405369-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 siRNA (h) - sc-63185 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UNC5H1 shRNA Plasmid (h) - sc-63185-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UNC5H1 shRNA (h) Lentiviral Particles - sc-63185-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UNC5H1/Unc5a RNAi - H00090249-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU159171 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22500 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22500 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07485 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07485

UNC5A siRNA (Human) - CRJ3919 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UNC5A - MBS8219139 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UNC5H1 CRISPR/Cas9 KO Plasmid (h2) - sc-405369-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UNC5H1 HDR Plasmid (h2) - sc-405369-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human Unc5a (NM_133369.2) - SHH440560 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human UNC5A(NM_133369.2) - SHL115056 from Creative biogene Category siRNA Species Reactivities Human

UNC5A shRNA Plasmid (Human) - CHJ3919 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UNC5A miRNA 3'UTR clone - MiUTR1H-11016 from Creative biogene Species Reactivities Human

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