Gene Symbol | EHD2 |
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Entrez Gene | 30846 |
Alt Symbol | PAST2 |
Species | Human |
Gene Type | protein-coding |
Description | EH-domain containing 2 |
Other Description | EH domain containing 2|EH domain-containing protein 2|PAST homolog 2 |
Swissprots | Q9NZN4 B2RDH9 Q96CB6 B4DNU6 |
Accessions | CAF06404 EAW57505 EAW57506 Q9NZN4 AF181263 AAF40470 AF454952 AAL51078 AK026134 AK074701 BAC11147 AK097126 AK097228 BAG53436 AK293429 BAG56934 AK296907 BAG59463 AK298067 BAG60358 AK300512 BAG62224 AK301380 BAH13468 AK315548 BAG37926 AK316448 BAH14819 BC014445 AAH14445 BG677716 DA094880 DB260808 DQ892835 ABM83761 DQ896082 ABM87081 NM_014601 NP_055416 |
Function | Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000269|PubMed:17233914}; Cytoplasmic side {ECO:0000269|PubMed:17233914}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. |
Top Pathways | Endocytosis |
Human EHD2 full length protein - ab132288 from Abcam
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Human EHD2 peptide - ab45619 from Abcam
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Human EHD2 protein fragment - ab162329 from Abcam
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EHD2 Antibody Blocking Peptide - LS-E25770 from LifeSpan Bioscience
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Recombinant Human EHD2 Protein - H00030846-P01 from Novus Biologicals
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EHD2 Partial Recombinant Protein - H00030846-Q01 from Novus Biologicals
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EHD2 blocking peptide - GTX89668-PEP from GeneTex
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EHD2 Peptide - AC21-0599-P from Abcore
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EHD2 - H00030846-P01-10 from Acris Antibodies
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EHD2 - H00030846-P01-25 from Acris Antibodies
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EHD2 - H00030846-Q01-10 from Acris Antibodies
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EHD2 - H00030846-Q01-25 from Acris Antibodies
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EHD2 Peptide - 45-523P from ProSci
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EHD2 fusion protein - ag2002 from Proteintech Group
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Recombinant Human EH domain-containing protein 2(EHD2) - CSB-YP873710HU CSB-EP873710HU CSB-BP873710HU CSB-MP873710HU from Cusabio
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EHD2 - TP304848 from Acris Antibodies
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EHD2, Peptide - MBS426788 from MyBioSource
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EHD2 Recombinant Protein Antigen - NBP2-33283PEP from Novus Biologicals
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EHD2-Blocking-Peptide-C-term - BP21050a from Abgent, a WuXi AppTec company
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EHD2 Peptide, Human - M34GP04780H from Creative Peptides
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EH domain-containing protein 2 (EHD2), Recombinant Protein - MBS1321371 from MyBioSource
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EHD2 Immunizing peptide - orb17407 from Biorbyt
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