Gene Symbol | EHD2 |
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Entrez Gene | 30846 |
Alt Symbol | PAST2 |
Species | Human |
Gene Type | protein-coding |
Description | EH-domain containing 2 |
Other Description | EH domain containing 2|EH domain-containing protein 2|PAST homolog 2 |
Swissprots | Q9NZN4 B2RDH9 Q96CB6 B4DNU6 |
Accessions | CAF06404 EAW57505 EAW57506 Q9NZN4 AF181263 AAF40470 AF454952 AAL51078 AK026134 AK074701 BAC11147 AK097126 AK097228 BAG53436 AK293429 BAG56934 AK296907 BAG59463 AK298067 BAG60358 AK300512 BAG62224 AK301380 BAH13468 AK315548 BAG37926 AK316448 BAH14819 BC014445 AAH14445 BG677716 DA094880 DB260808 DQ892835 ABM83761 DQ896082 ABM87081 NM_014601 NP_055416 |
Function | Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000269|PubMed:17233914}; Cytoplasmic side {ECO:0000269|PubMed:17233914}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. |
Top Pathways | Endocytosis |
EHD2 (E-20) - sc-70264 from Santa Cruz Biotechnology
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EHD2 (C-18) - sc-70263 from Santa Cruz Biotechnology
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EHD2 (Q-12) - sc-70266 from Santa Cruz Biotechnology
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EHD2 (L-05) - sc-100724 from Santa Cruz Biotechnology
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Anti-EHD2 antibody - ab118356 from Abcam
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Anti-EHD2 antibody [EPR9820] - ab154807 from Abcam
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Anti-EHD2 antibody [EPR9821] - ab154784 from Abcam
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Anti-EHD2 Antibody (aa365-428, clone 10C43, Azide-free) - LS-C183588 from LifeSpan Bioscience
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Anti-EHD2 Antibody (aa365-428) - LS-C307355 from LifeSpan Bioscience
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Anti-EHD2 Antibody (aa529-542) IHC-plus⢠- LS-B10279 from LifeSpan Bioscience
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EHD2 Antibody (2D8) - H00030846-M01 from Novus Biologicals
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EHD2 Antibody - NBP2-33283 from Novus Biologicals
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EHD2 Antibody - NB100-1458 from Novus Biologicals
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EHD2 Antibody - 30780002 from Novus Biologicals
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EHD2 Antibody - H00030846-A01 from Novus Biologicals
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Monoclonal Anti-EHD2 antibody produced in mouse - SAB1405066 from Sigma-Aldrich
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Anti-EHD2 antibody produced in goat - SAB2500345 from Sigma-Aldrich
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Anti-EHD2 antibody produced in rabbit - HPA047394 from Sigma-Aldrich
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EHD2-Antibody-monoclonal-M01 - AT1866a from Abgent, a WuXi AppTec company
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EHD2-Antibody - AF1358a from Abgent, a WuXi AppTec company
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EHD2-Antibody-C-term - AP21050a from Abgent, a WuXi AppTec company
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EHD2-Antibody-C-term - AW5422 from Abgent, a WuXi AppTec company
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EHD2 antibody [C3], C-term - GTX107699 from GeneTex
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EHD2 antibody, C-term - GTX89668 from GeneTex
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EHD2 Antibody (OAEB01778) - OAEB01778 from Aviva Systems Biology
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