| Gene Symbol |
DAZL
|
| Entrez Gene |
1618
|
| Alt Symbol |
DAZH, DAZL1, DAZLA, SPGYLA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deleted in azoospermia-like
|
| Other Description |
DAZ homolog|DAZ-like autosomal|SPGY-like-autosomal|deleted in azoospermia-like 1|germline specific RNA binding protein|spermatogenesis gene on the Y-like autosomal
|
| Swissprots |
O15396 Q5HYB4 Q92904 Q92909
|
| Accessions |
AAB84361 ABK58591 CBH19255 EAW64278 EAW64279 Q92904 AK303026 BAG64152 AK310341 BC027595 AAH27595 BX648638 CAI45996 DB080081 DQ576044 EU176226 ABW03677 U65918 AAC50813 U66078 AAB63596 U66726 AAB39935 NM_001190811 NP_001177740 NM_001351 NP_001342
|
| Function |
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.
|
| Tissue Specificity |
Testis specific. {ECO:0000269|PubMed:8896558, ECO:0000269|PubMed:8968755, ECO:0000269|PubMed:8968756}.
|
![Western Blot: DAZL Overexpression Lysate (Adult Normal) [NBL1-09725] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DAZL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8361_DAZL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09725-img0002.jpg)