| Gene Symbol |
UGT1A5
|
| Entrez Gene |
54579
|
| Alt Symbol |
UDPGT, UDPGT 1-5, UGT1E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A5
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A5|UDP-glucuronosyltransferase 1 family polypeptide A5s|UDP-glucuronosyltransferase 1-5|UDP-glucuronosyltransferase 1-E|UDP-glucuronosyltransferase 1A5|UGT-1E|UGT1*5
|
| Swissprots |
B8K294 P35504
|
| Accessions |
AAA61250 AAG30421 AAQ03151 AAQ03152 AAQ03153 AAQ03154 AAQ03155 AAQ03156 AAQ03157 BAK32964 BAK32965 BAK32966 EAW71059 P35504 AY435140 AAR95641 BC141470 AAI41471 DQ383514 ABD42927 NM_019078 NP_061951
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus. {ECO:0000269|PubMed:18004212}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|