Gene Symbol | UGT1A5 |
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Entrez Gene | 54579 |
Alt Symbol | UDPGT, UDPGT 1-5, UGT1E |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 1 family, polypeptide A5 |
Other Description | UDP glycosyltransferase 1 family, polypeptide A5|UDP-glucuronosyltransferase 1 family polypeptide A5s|UDP-glucuronosyltransferase 1-5|UDP-glucuronosyltransferase 1-E|UDP-glucuronosyltransferase 1A5|UGT-1E|UGT1*5 |
Swissprots | B8K294 P35504 |
Accessions | AAA61250 AAG30421 AAQ03151 AAQ03152 AAQ03153 AAQ03154 AAQ03155 AAQ03156 AAQ03157 BAK32964 BAK32965 BAK32966 EAW71059 P35504 AY435140 AAR95641 BC141470 AAI41471 DQ383514 ABD42927 NM_019078 NP_061951 |
Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}. |
Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus. {ECO:0000269|PubMed:18004212}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT1A5 CRISPR/Cas9 KO Plasmid (h) - sc-402838 from Santa Cruz Biotechnology
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UGT1A5 HDR Plasmid (h) - sc-402838-HDR from Santa Cruz Biotechnology
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UGT1A5 Double Nickase Plasmid (h) - sc-402838-NIC from Santa Cruz Biotechnology
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UGT1A5 Double Nickase Plasmid (h2) - sc-402838-NIC-2 from Santa Cruz Biotechnology
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UGT1A5 CRISPR Activation Plasmid (h) - sc-402838-ACT from Santa Cruz Biotechnology
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UGT1A5 CRISPR Activation Plasmid (h2) - sc-402838-ACT-2 from Santa Cruz Biotechnology
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UGT1A5 Lentiviral Activation Particles (h) - sc-402838-LAC from Santa Cruz Biotechnology
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UGT1A5 Lentiviral Activation Particles (h2) - sc-402838-LAC-2 from Santa Cruz Biotechnology
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UGT1A5 siRNA (h) - sc-44473 from Santa Cruz Biotechnology
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UGT1A5 shRNA Plasmid (h) - sc-44473-SH from Santa Cruz Biotechnology
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UGT1A5 shRNA (h) Lentiviral Particles - sc-44473-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN22460 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22460 from Sigma-Aldrich
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UGT1A5 siRNA (Human) - CRJ0144 from Cohesion Biosciences
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UGT1A5 - MBS8233320 from MyBioSource
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shRNA set against Human UGT1A5 (NM_019078.1) - SHH440084 from Creative biogene
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shRNA set against Human UGT1A5(NM_019078.1) - SHL112962 from Creative biogene
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Human UGT1A5 siRNA - orb270645 from Biorbyt
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UGT1A5 shRNA Plasmid (Human) - CHJ0144 from Cohesion Biosciences
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UGT1A5 miRNA 3'UTR clone - MiUTR1H-10992 from Creative biogene
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