Gene Symbol | UGT1A5 |
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Entrez Gene | 54579 |
Alt Symbol | UDPGT, UDPGT 1-5, UGT1E |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 1 family, polypeptide A5 |
Other Description | UDP glycosyltransferase 1 family, polypeptide A5|UDP-glucuronosyltransferase 1 family polypeptide A5s|UDP-glucuronosyltransferase 1-5|UDP-glucuronosyltransferase 1-E|UDP-glucuronosyltransferase 1A5|UGT-1E|UGT1*5 |
Swissprots | B8K294 P35504 |
Accessions | AAA61250 AAG30421 AAQ03151 AAQ03152 AAQ03153 AAQ03154 AAQ03155 AAQ03156 AAQ03157 BAK32964 BAK32965 BAK32966 EAW71059 P35504 AY435140 AAR95641 BC141470 AAI41471 DQ383514 ABD42927 NM_019078 NP_061951 |
Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}. |
Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus. {ECO:0000269|PubMed:18004212}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT1A5 (L-12) - sc-27428 from Santa Cruz Biotechnology
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Anti-UGT1A5 antibody - ab105780 from Abcam
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Anti-UGT1A5 Antibody (aa71-120) IHC-plus⢠- LS-B11515 from LifeSpan Bioscience
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UGT1A5 Antibody - NBP1-91336 from Novus Biologicals
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Anti-UGT1A5, (N-terminal) antibody produced in rabbit - SAB2105725 from Sigma-Aldrich
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UGT1A5 antibody - N-terminal region (ARP49439_P050) - ARP49439_P050 from Aviva Systems Biology
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UGT1A5 antibody - H00054579-B01P from Acris Antibodies
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UGT1A5 Antibody - GWB-MR504I from Genway Biotech
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Anti-UGT1A5 monoclonal antibody - DCABH-13915 from Creative Diagnostics
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UGT1A5-antibody-N-terminal-region-AI13024 - AI13024 from Abgent, a WuXi AppTec company
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UGT1A5, Polyclonal Antibody - MBS5301016 from MyBioSource
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UGT1A5 antibody - TA331083 from Acris Antibodies
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Anti-UGT1A5 (aa 71-120) polyclonal antibody - CABT-BL5947 from Creative Diagnostics
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Anti-UGT1A5 Antibody A10934 - A10934 from Boster Bio
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UGT1A5 antibody - N-terminal region : Biotin (ARP49439_P050-Biotin) - ARP49439_P050-Biotin from Aviva Systems Biology
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UGT1A5 antibody - N-terminal region : FITC (ARP49439_P050-FITC) - ARP49439_P050-FITC from Aviva Systems Biology
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UGT1A5 antibody - N-terminal region : HRP (ARP49439_P050-HRP) - ARP49439_P050-HRP from Aviva Systems Biology
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UGT1A5 Antibody - middle region (ARP77428_P050) - ARP77428_P050 from Aviva Systems Biology
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Anti-UGT1A5 Antibody (aa71-120, FITC) - LS-C452347 from LifeSpan Bioscience
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Anti-UGT1A5 Antibody (aa71-120, Biotin) - LS-C452348 from LifeSpan Bioscience
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Anti-UGT1A5 Antibody (aa71-120, HRP) - LS-C452349 from LifeSpan Bioscience
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