| Gene Symbol |
SHROOM3
|
| Entrez Gene |
57619
|
| Alt Symbol |
APXL3, MSTP013, SHRM, ShrmL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
shroom family member 3
|
| Other Description |
F-actin-binding protein|protein Shroom3|shroom-related protein
|
| Swissprots |
Q5QTQ3 Q9P247 Q96IR9 Q6ZRW3 Q8TF72
|
| Accessions |
EAX05794 EAX05795 Q8TF72 AB040914 BAA96005 AB055660 BAB84689 AF109367 AAQ13515 AK027744 BAB55336 AK055294 AK097800 AK124415 BAC85848 AK127929 BAC87195 AK128677 BAG54709 AK304103 BAG65006 AW025141 BC007291 AAH07291 BC156132 AAI56133 HG496999 XM_005263162 XP_005263219 XM_005263163 XP_005263220 XM_005263164 XP_005263221 XM_005263165 XP_005263222 XM_006714282 XP_006714345 XM_011532157 XP_011530459 XM_011532158 XP_011530460 XM_011532159 XP_011530461 XM_011532160 XP_011530462 XM_011532161 XP_011530463 NM_020859 NP_065910
|
| Function |
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with F-actin in stress fibers and adherens junctions. {ECO:0000250}.
|
| Top Pathways |
Tight junction
|