P4HB

Gene Symbol	P4HB
Entrez Gene	5034
Alt Symbol	CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Species	Human
Gene Type	protein-coding
Description	prolyl 4-hydroxylase, beta polypeptide
Other Description	cellular thyroid hormone-binding protein|collagen prolyl 4-hydroxylase beta|glutathione-insulin transhydrogenase|p55|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide|prolyl 4-hydroxylase subunit beta|protein disulfide isomerase family A, member 1|protein disulfide isomerase-associated 1|protein disulfide isomerase/oxidoreductase|protein disulfide-isomerase|protocollagen hydroxylase|thyroid hormone-binding protein p55
Swissprots	P30037 P32079 Q6LDE5 B2RDQ2 P07237 Q15205
Accessions	AAB22262 AAC13652 CCQ43001 CDM55388 CDM55569 EAW89690 EAW89691 EAW89692 EAW89693 EAW89694 EAW89695 EAW89696 P07237 AB062434 BAB93497 AK075503 AK095938 BAG53171 AK128783 BAG54732 AK296206 BAG58932 AK297081 BAG59598 AK297967 BAG60277 AK298005 BAG60311 AK300561 BAG62267 AK308600 AK315631 BAG37999 AU131354 BC010859 AAH10859 BC014504 AAH14504 BC018801 BC029617 AAH29617 BC071892 AAH71892 BX353203 CA412209 DB466371 J02783 AAA61169 JF432204 ADZ15421 X05130 CAA28775 X07077 CAA30112 NM_000918 NP_000909
Function	This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997}.
Subcellular Location	Endoplasmic reticulum lumen. Melanosome. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000305}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human P4HB full length protein - ab73280 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli Species Human

Human P4HB full length protein - ab115719 from Abcam Category Protein Source E. coli Species Human

Recombinant Human Protein Disulfide Isomerase/P4HB Protein - H00005034-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Protein Disulfide Isomerase/P4HB Protein - NBP1-45320 from Novus Biologicals Category Protein Prices $299.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Recombinant Human Protein Disulfide Isomerase/P4HB Protein - NBP1-99878 from Novus Biologicals Category Protein Prices $195.00 Sizes 100 µg Source E. coli Species Human

P4HB-Antibody-C-term-Blocking-Peptide - BP2911b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human P4HB, CF - 4236-DI-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Asp18-Lys505, with a C-terminal 10-His tag

P4HB Protein (AEP10025) - AEP10025 from Aviva Systems Biology Category Protein Prices $199.00 Sizes 100 µg Species Human

P4HB Protein (OPPA02423) - OPPA02423 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human P4hb protein - orb246406 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Protein Disulfide Isomerase protein - orb163493 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human P4hb protein - orb245949 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human P4HB protein - orb90204 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli Species Human

Human ERBA2L protein - orb83219 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human ERBA2L protein - orb245024 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

P4HB Blocking Peptide - 33R-9118 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

P4HB Blocking Peptide - 33R-2152 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human PDI Protein - abx068737 from Abbexa Category Protein Source E.coli Species Human

PDI / P4HB (18-508, His-tag) - AR09608PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PDI / P4HB (18-508, His-tag) - AR09608PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PDI / P4HB - H00005034-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PDI / P4HB - H00005034-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Protein Disulfide Isomerase, Human Recombinant - 228-11217-1 from RayBiotech Category Protein Prices $252.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human PDI - 228-11217-2 from RayBiotech Category Protein Prices $748.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human PDI - 228-11217-3 from RayBiotech Category Protein Prices $1,275.00 Sizes 3 µg Source Escherichia Coli. Species Human

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