Gene Symbol | UBIAD1 |
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Entrez Gene | 29914 |
Alt Symbol | SCCD, TERE1 |
Species | Human |
Gene Type | protein-coding |
Description | UbiA prenyltransferase domain containing 1 |
Other Description | transitional epithelia response protein|transitional epithelial response protein 1|ubiA prenyltransferase domain-containing protein 1 |
Swissprots | B3KQG3 Q9Y5Z9 Q5THD4 Q53GX3 |
Accessions | CAF86981 EAW71686 Q9Y5Z9 AA505091 AF117064 AAD27581 AK027433 AK074487 AK074890 BAG52025 AK222808 BAD96528 BC004468 AAH04468 BT006832 AAP35478 BX507524 XM_006710590 XP_006710653 XM_011541304 XP_011539606 XR_946616 NM_013319 NP_037451 |
Function | Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {ECO:0000269|PubMed:20953171, ECO:0000269|PubMed:23374346}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11314041}. |
TERE1 (H-8) - sc-377013 from Santa Cruz Biotechnology
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TERE1 (N-16) - sc-47474 from Santa Cruz Biotechnology
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TERE1 (H-205) - sc-98964 from Santa Cruz Biotechnology
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TERE1 (C-18) - sc-47471 from Santa Cruz Biotechnology
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Anti-UBIAD1 antibody - ab93413 from Abcam
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Anti-UBIAD1 antibody - C-terminal - ab191691 from Abcam
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Anti-TERE1 / UBIAD1 Antibody (aa32-45) - LS-C40741 from LifeSpan Bioscience
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Anti-TERE1 / UBIAD1 Antibody - LS-C153073 from LifeSpan Bioscience
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Anti-TERE1 / UBIAD1 Antibody (aa32-45) IHC-plus⢠- LS-B317 from LifeSpan Bioscience
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Anti-TERE1 / UBIAD1 Antibody (C-Terminus) IHC-plus⢠- LS-B12058 from LifeSpan Bioscience
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UBIAD1 Antibody - NB100-468 from Novus Biologicals
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UBIAD1 Antibody - NBP1-87080 from Novus Biologicals
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Anti-UBIAD1 antibody produced in rabbit - HPA038200 from Sigma-Aldrich
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TERE1 antibody - 70R-TR001 from Fitzgerald
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UBIAD1 / TERE1 antibody - PAB1082 from Acris Antibodies
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Anti-UBIAD1 Antibody - AC11-0271 from Abcore
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Rabbit Anti-Human TERE1 - 114-10179 from RayBiotech
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UBIAD1 Antibody - 7751 from ProSci
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TERE1, Polyclonal Antibody - MBS194440 from MyBioSource
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TERE1, Polyclonal Antibody - MBS534983 from MyBioSource
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UBIAD1, Polyclonal Antibody - MBS153471 from MyBioSource
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Anti- TERE1 Antibody - GWB-6C9DF5 from Genway Biotech
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Anti-UBIAD1 monoclonal antibody - DCABH-13900 from Creative Diagnostics
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TERE1 Polyclonal Antibody - PA1-10887 from Thermo Fisher Scientific
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TERE1 Polyclonal Antibody - PA1-4378 from Thermo Fisher Scientific
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