| Gene Symbol |
UBIAD1
|
| Entrez Gene |
29914
|
| Alt Symbol |
SCCD, TERE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UbiA prenyltransferase domain containing 1
|
| Other Description |
transitional epithelia response protein|transitional epithelial response protein 1|ubiA prenyltransferase domain-containing protein 1
|
| Swissprots |
B3KQG3 Q9Y5Z9 Q5THD4 Q53GX3
|
| Accessions |
CAF86981 EAW71686 Q9Y5Z9 AA505091 AF117064 AAD27581 AK027433 AK074487 AK074890 BAG52025 AK222808 BAD96528 BC004468 AAH04468 BT006832 AAP35478 BX507524 XM_006710590 XP_006710653 XM_011541304 XP_011539606 XR_946616 NM_013319 NP_037451
|
| Function |
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {ECO:0000269|PubMed:20953171, ECO:0000269|PubMed:23374346}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11314041}.
|