CRBN

Gene Symbol	CRBN
Entrez Gene	51185
Alt Symbol	MRT2, MRT2A
Species	Human
Gene Type	protein-coding
Description	cereblon
Other Description	protein cereblon|protein x 0001
Swissprots	Q6NVZ0 C9JAH6 C9IZA9 B2R6H4 Q9UHW4 Q96SW2 Q6AI62
Accessions	EAW63890 EAW63891 EAW63892 EAW63893 EAW63894 EAW63895 EAW63896 EAW63897 Q96SW2 AA991754 AF117230 AAF17211 AK027507 BAB55162 AK058191 AK123077 AK301423 BAG62951 AK312577 BAG35471 AL711072 BC017419 AAH17419 BC059171 BC067811 AAH67811 BX647351 CR627060 CAH10361 DB456585 HQ447457 ADQ31943 JF432198 ADZ15415 XM_005265202 XP_005265259 XM_011533791 XP_011532093 XM_011533792 XP_011532094 XM_011533793 XP_011532095 XM_011533794 XP_011532096 XR_940448 NM_001173482 NP_001166953 NM_016302 NP_057386
Function	Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. {ECO:0000269|PubMed:18414909, ECO:0000269|PubMed:20223979, ECO:0000269|PubMed:24328678, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20223979}. Nucleus {ECO:0000269|PubMed:20223979}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. Highly expressed in brain. {ECO:0000269|PubMed:15557513, ECO:0000269|PubMed:17380424}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CRBN / Cereblon ELISA Kit (Sandwich ELISA) - LS-F9761 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Mouse CRBN / Cereblon ELISA Kit (Sandwich ELISA) - LS-F9762 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human CRBN / Cereblon ELISA Kit (Sandwich ELISA) - LS-F11209 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human Cereblon ELISA Kit - abx151037 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Cereblon (CRBN), Human, ELISA Kit - SEG676Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Protein cereblon (CRBN), Human, ELISA Kit - CSB-EL005944HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Protein cereblon, CRBN, Human, ELISA Kit - E12793h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

cereblon, ELISA Kit - MBS911772 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 9.38 pg/ml. Range 37.5 pg/ml -2400 pg/ml.

Cereblon (CRBN), ELISA Kit - MBS2024471 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CRBN is typically less than 0.125ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

Cereblon (CRBN), ELISA Kit - MBS2020696 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.057ng/mL. Range 0.156-10ng/mL

Cereblon (CRBN), ELISA Kit - MBS9301860 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Cereblon (CRBN) - SEG676Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Cereblon (CRBN) - SEG676Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Protein cereblon(CRBN) ELISA kit - CSB-EL005944HU from Cusabio Category ELISA Kit Sensitivity 9.38 pg/ml. Range 37.5 pg/ml-2400 pg/ml

ELISA Kit for Cereblon (CRBN) - SEG676Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat CRBN / Cereblon ELISA Kit (Custom ELISA) - LS-F16728 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse CRBN / Cereblon ELISA Kit (Custom ELISA) - LS-F16727 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine CRBN / Cereblon ELISA Kit (Custom ELISA) - LS-F16730 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Chicken CRBN / Cereblon ELISA Kit (Custom ELISA) - LS-F16729 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Cereblon (CRBN) ELISA Kit - EKU03077 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.057 ng/mL Range 0.156-10 ng/mL

Human Protein cereblon ELISA Kit - abx250736 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Cereblon (CRBN), Human, ELISA Kit - DL-CRBN-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.31-20 ng/ml

Human CRBN ELISA Kit - abx573109 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Protein cereblon(CRBN) ELISA Kit - EKC35181 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 9.38 pg/ml Range 37.5 pg/ml-2400 pg/ml

Human Protein cereblon ELISA Kit - EKE53229 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.2 ng/ml Range 0.312-20 ng/mL

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