| Gene Symbol |
CRBN
|
| Entrez Gene |
51185
|
| Alt Symbol |
MRT2, MRT2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cereblon
|
| Other Description |
protein cereblon|protein x 0001
|
| Swissprots |
Q6NVZ0 C9JAH6 C9IZA9 B2R6H4 Q9UHW4 Q96SW2 Q6AI62
|
| Accessions |
EAW63890 EAW63891 EAW63892 EAW63893 EAW63894 EAW63895 EAW63896 EAW63897 Q96SW2 AA991754 AF117230 AAF17211 AK027507 BAB55162 AK058191 AK123077 AK301423 BAG62951 AK312577 BAG35471 AL711072 BC017419 AAH17419 BC059171 BC067811 AAH67811 BX647351 CR627060 CAH10361 DB456585 HQ447457 ADQ31943 JF432198 ADZ15415 XM_005265202 XP_005265259 XM_011533791 XP_011532093 XM_011533792 XP_011532094 XM_011533793 XP_011532095 XM_011533794 XP_011532096 XR_940448 NM_001173482 NP_001166953 NM_016302 NP_057386
|
| Function |
Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. {ECO:0000269|PubMed:18414909, ECO:0000269|PubMed:20223979, ECO:0000269|PubMed:24328678, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000305}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20223979}. Nucleus {ECO:0000269|PubMed:20223979}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in brain. {ECO:0000269|PubMed:15557513, ECO:0000269|PubMed:17380424}.
|