CRBN

Gene Symbol	CRBN
Entrez Gene	51185
Alt Symbol	MRT2, MRT2A
Species	Human
Gene Type	protein-coding
Description	cereblon
Other Description	protein cereblon|protein x 0001
Swissprots	Q6NVZ0 C9JAH6 C9IZA9 B2R6H4 Q9UHW4 Q96SW2 Q6AI62
Accessions	EAW63890 EAW63891 EAW63892 EAW63893 EAW63894 EAW63895 EAW63896 EAW63897 Q96SW2 AA991754 AF117230 AAF17211 AK027507 BAB55162 AK058191 AK123077 AK301423 BAG62951 AK312577 BAG35471 AL711072 BC017419 AAH17419 BC059171 BC067811 AAH67811 BX647351 CR627060 CAH10361 DB456585 HQ447457 ADQ31943 JF432198 ADZ15415 XM_005265202 XP_005265259 XM_011533791 XP_011532093 XM_011533792 XP_011532094 XM_011533793 XP_011532095 XM_011533794 XP_011532096 XR_940448 NM_001173482 NP_001166953 NM_016302 NP_057386
Function	Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. {ECO:0000269|PubMed:18414909, ECO:0000269|PubMed:20223979, ECO:0000269|PubMed:24328678, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20223979}. Nucleus {ECO:0000269|PubMed:20223979}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. Highly expressed in brain. {ECO:0000269|PubMed:15557513, ECO:0000269|PubMed:17380424}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CRBN full length protein - ab162449 from Abcam Category Protein Source Wheat germ Species Human

Human CRBN protein fragment - ab162450 from Abcam Category Protein Source Wheat germ Species Human

CRBN / Cereblon Antibody Blocking Peptide - LS-E20722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CRBN Protein - H00051185-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CRBN Protein - H00051185-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CRBN Blocking Peptide - NBP1-56305PEP from Novus Biologicals Category Peptide Prices $169.00 Sizes 100 µg Species Human

CRBN Blocking Peptide - 33R-2125 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cereblon - H00051185-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cereblon - H00051185-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cereblon - H00051185-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cereblon - H00051185-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CRBN Peptide - 8115P from ProSci Category Peptide Species Human

CRBN fusion protein - ag1951 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CRBN fusion protein - ag17166 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Cereblon (CRBN) - RPG676Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cereblon (CRBN) - RPG676Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cereblon (CRBN) - RPG676Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cereblon (CRBN) - RPG676Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protein cereblon(CRBN) - CSB-YP842761HU CSB-EP842761HU CSB-BP842761HU CSB-MP842761HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CRBN Recombinant Protein Antigen - NBP1-91810PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Homo sapiens (Human) Protein cereblon - CSB-EP842761HU from Cusabio Category Protein Source E.coli Species Human

CRBN Peptide, Human - M34GP03616H from Creative Peptides Category Peptide Source Synthetic. Species Human

CRBN Antibody - SH-A11275 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

Human CRBN protein - orb383449 from Biorbyt Category Protein Prices $544.00, $1,071.00, $1,488.00 Sizes 20 μg, 50 μg, 100 μg Species Human

Human CRBN protein - orb54697 from Biorbyt Category Protein Prices $859.00, $910.00, $1,190.00 Sizes 10 μg, 50 μg, 100 μg Species Human

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