RASGRP4

Gene Symbol	RASGRP4
Entrez Gene	115727
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	RAS guanyl releasing protein 4
Other Description	RAS guanyl-releasing protein 4|guanyl nucleotide releasing protein 4
Swissprots	Q96QN7 Q96QN5 C9J416 C0LTP3 C0LTP7 Q8N858 C0LTP4 Q96QN6 A6H8M4 C0LTP2 C9JHZ1 Q8TDF6 C0LTP5
Accessions	EAW56794 Q8TDF6 AF448437 AAL87858 AK097292 AY048119 AAK85701 AY048120 AAK85702 AY048121 AAK85703 BC142721 BC146669 AAI46670 BC150202 AAI50203 BC151216 BQ028385 FJ768677 ACN82414 FJ768678 ACN82415 FJ768679 ACN82416 FJ768680 ACN82417 FJ768681 ACN82418 FJ768682 ACN82419 XR_935732 NM_001146202 NP_001139674 NM_001146203 NP_001139675 NM_001146204 NP_001139676 NM_001146205 NP_001139677 NM_001146206 NP_001139678 NM_001146207 NP_001139679 NM_170604 NP_733749 NM_052949 NM_170602 NM_170603
Function	Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. {ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}.
Subcellular Location	Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.
Tissue Specificity	Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient. {ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RASGRP4 293T Cell Transient Overexpression Lysate(Denatured) - H00115727-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RASGRP4 overexpression lysate - LY406913 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

RASGRP4 overexpression lysate - LY431425 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RASGRP4 overexpression lysate - LY431496 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RASGRP4 overexpression lysate - LY431521 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RASGRP4 overexpression lysate - LY431540 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RASGRP 4 Overexpression Lysate (Denatured) - H00115727-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

RASGRP 4 Overexpression Lysate (Native) - NBP2-05215 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

RasGRP4 (h): 293T Lysate - sc-112624 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RasGRP4 (h2): 293T Lysate - sc-112846 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Panoply™ Human RASGRP4 Knockdown Stable Cell Line - CSC-DC013002 from Creative biogene Category Cell Line Species Human

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