RASGRP4

Gene Symbol RASGRP4
Entrez Gene 115727
Alt Symbol -
Species Human
Gene Type protein-coding
Description RAS guanyl releasing protein 4
Other Description RAS guanyl-releasing protein 4|guanyl nucleotide releasing protein 4
Swissprots Q96QN7 Q96QN5 C9J416 C0LTP3 C0LTP7 Q8N858 C0LTP4 Q96QN6 A6H8M4 C0LTP2 C9JHZ1 Q8TDF6 C0LTP5
Accessions EAW56794 Q8TDF6 AF448437 AAL87858 AK097292 AY048119 AAK85701 AY048120 AAK85702 AY048121 AAK85703 BC142721 BC146669 AAI46670 BC150202 AAI50203 BC151216 BQ028385 FJ768677 ACN82414 FJ768678 ACN82415 FJ768679 ACN82416 FJ768680 ACN82417 FJ768681 ACN82418 FJ768682 ACN82419 XR_935732 NM_001146202 NP_001139674 NM_001146203 NP_001139675 NM_001146204 NP_001139676 NM_001146205 NP_001139677 NM_001146206 NP_001139678 NM_001146207 NP_001139679 NM_170604 NP_733749 NM_052949 NM_170602 NM_170603
Function Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. {ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}.
Subcellular Location Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.
Tissue Specificity Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient. {ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218}.
Top Pathways MAPK signaling pathway

RasGRP4 CRISPR/Cas9 KO Plasmid (h) - sc-405412 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 HDR Plasmid (h) - sc-405412-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 Double Nickase Plasmid (h) - sc-405412-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 Double Nickase Plasmid (h2) - sc-405412-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 CRISPR Activation Plasmid (h) - sc-405412-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 CRISPR Activation Plasmid (h2) - sc-405412-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 Lentiviral Activation Particles (h) - sc-405412-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 Lentiviral Activation Particles (h2) - sc-405412-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RasGRP4 siRNA (h) - sc-97242 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RasGRP4 shRNA Plasmid (h) - sc-97242-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RasGRP4 shRNA (h) Lentiviral Particles - sc-97242-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RASGRP 4 RNAi - H00115727-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU149001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17987 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17987 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08216 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08216

RASGRP4 siRNA (Human) - CRJ4463 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RASGRP4 - MBS828185 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RASGRP4 (NM_170604.2) - SHH390060 from Creative biogene

Category siRNA
Species Reactivities Human

Human RASGRP4 siRNA - orb274964 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RASGRP4 shRNA Plasmid (Human) - CHJ4463 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RASGRP4 miRNA 3'UTR clone - MiUTR3H-09135 from Creative biogene

Species Reactivities Human

RASGRP4 miRNA 3'UTR clone - MiUTR3H-09136 from Creative biogene

Species Reactivities Human

RASGRP4 miRNA 3'UTR clone - MiUTR3H-09137 from Creative biogene

Species Reactivities Human

RASGRP4 miRNA 3'UTR clone - MiUTR3H-09138 from Creative biogene

Species Reactivities Human
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