PLEKHO1

Gene Symbol	PLEKHO1
Entrez Gene	51177
Alt Symbol	CKIP-1, JBP, OC120
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology domain containing, family O member 1
Other Description	C-Jun-binding protein|CK2 interacting protein 1; HQ0024c protein|CK2-interacting protein 1|PH domain-containing family O member 1|casein kinase 2-interacting protein 1|osteoclast maturation-associated gene 120 protein|pleckstrin homology domain-containing family O member 1
Swissprots	Q9NRV3 Q8IZ51 Q53GL0 Q9UL48 Q336K5
Accessions	CAI14262 CAI14263 CAI14264 EAW53580 EAW53581 EAW53582 EAW53583 Q53GL0 AF073836 AAF13461 AF168676 AAF89644 AF192912 AAQ13826 AF217956 AAK71509 AF291105 AAK28027 AK025937 AK125609 AK222921 BAD96641 AK302255 BAG63607 AM392528 CAL37406 AM392600 CAL37478 AM393378 CAL38256 BC010149 AAH10149 BC023533 AAH23533 BP329810 BX353413 BX376480 BX394578 DA604331 DB023901 DQ893381 ABM84307 DQ896780 ABM87779 HY006501 NM_001304722 NP_001291651 NM_001304723 NP_001291652 NM_001304724 NP_001291653 NM_016274 NP_057358
Function	Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}.
Subcellular Location	Cell membrane. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Tissue Specificity	Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. {ECO:0000269|PubMed:17197158}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CKIP-1 (A-12) - sc-376355 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CKIP-1 (A-3) - sc-376060 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CKIP-1 (C-20) - sc-50224 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CKIP-1 (H-240) - sc-99218 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CKIP-1 (S-20) - sc-50227 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CKIP-1 (E-18) - sc-50226 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CKIP-1 (D-20) - sc-50225 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PLEKHO1 antibody - ab91489 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PLEKHO1 antibody - ab89110 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PLEKHO1 antibody - ab113663 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PLEKHO1 / CKIP-1 Antibody (C-Terminus) IHC-plus™ - LS-B5042 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PLEKHO1 / CKIP-1 Antibody (N-Terminus) - LS-C116343 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PLEKHO1 / CKIP-1 Antibody (clone 1C7) - LS-C134065 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C7

Anti-PLEKHO1 / CKIP-1 Antibody (aa49-77) - LS-C168797 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CKIP-1 Antibody - NBP1-76238 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CKIP-1 Antibody - H00051177-B01P from Novus Biologicals Prices $349.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CKIP-1 Antibody - NBP1-56986 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Antibody (3D5) - H00051177-M01A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 3D5

CKIP-1 Antibody (1C7) - H00051177-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C7

CKIP-1 Polyclonal Antibody - bs-1330R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-1330R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-1330R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-1330R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-1330R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CKIP-1 Polyclonal Antibody, Cy3 Conjugated - bs-1330R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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