| Gene Symbol |
PLEKHO1
|
| Entrez Gene |
51177
|
| Alt Symbol |
CKIP-1, JBP, OC120
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family O member 1
|
| Other Description |
C-Jun-binding protein|CK2 interacting protein 1; HQ0024c protein|CK2-interacting protein 1|PH domain-containing family O member 1|casein kinase 2-interacting protein 1|osteoclast maturation-associated gene 120 protein|pleckstrin homology domain-containing family O member 1
|
| Swissprots |
Q9NRV3 Q8IZ51 Q53GL0 Q9UL48 Q336K5
|
| Accessions |
CAI14262 CAI14263 CAI14264 EAW53580 EAW53581 EAW53582 EAW53583 Q53GL0 AF073836 AAF13461 AF168676 AAF89644 AF192912 AAQ13826 AF217956 AAK71509 AF291105 AAK28027 AK025937 AK125609 AK222921 BAD96641 AK302255 BAG63607 AM392528 CAL37406 AM392600 CAL37478 AM393378 CAL38256 BC010149 AAH10149 BC023533 AAH23533 BP329810 BX353413 BX376480 BX394578 DA604331 DB023901 DQ893381 ABM84307 DQ896780 ABM87779 HY006501 NM_001304722 NP_001291651 NM_001304723 NP_001291652 NM_001304724 NP_001291653 NM_016274 NP_057358
|
| Function |
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}.
|
| Subcellular Location |
Cell membrane. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
|
| Tissue Specificity |
Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. {ECO:0000269|PubMed:17197158}.
|
![Western Blot: CKIP-1 Overexpression Lysate (Adult Normal) [NBL1-14512] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CKIP-1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12836_CKIP-1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14512-img0002.jpg)