PLEKHO1

Gene Symbol	PLEKHO1
Entrez Gene	51177
Alt Symbol	CKIP-1, JBP, OC120
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology domain containing, family O member 1
Other Description	C-Jun-binding protein|CK2 interacting protein 1; HQ0024c protein|CK2-interacting protein 1|PH domain-containing family O member 1|casein kinase 2-interacting protein 1|osteoclast maturation-associated gene 120 protein|pleckstrin homology domain-containing family O member 1
Swissprots	Q9NRV3 Q8IZ51 Q53GL0 Q9UL48 Q336K5
Accessions	CAI14262 CAI14263 CAI14264 EAW53580 EAW53581 EAW53582 EAW53583 Q53GL0 AF073836 AAF13461 AF168676 AAF89644 AF192912 AAQ13826 AF217956 AAK71509 AF291105 AAK28027 AK025937 AK125609 AK222921 BAD96641 AK302255 BAG63607 AM392528 CAL37406 AM392600 CAL37478 AM393378 CAL38256 BC010149 AAH10149 BC023533 AAH23533 BP329810 BX353413 BX376480 BX394578 DA604331 DB023901 DQ893381 ABM84307 DQ896780 ABM87779 HY006501 NM_001304722 NP_001291651 NM_001304723 NP_001291652 NM_001304724 NP_001291653 NM_016274 NP_057358
Function	Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}.
Subcellular Location	Cell membrane. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Tissue Specificity	Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. {ECO:0000269|PubMed:17197158}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PLEKHO1 full length protein - ab162446 from Abcam Category Protein Source Wheat germ Species Human

PLEKHO1 / CKIP-1 Antibody Blocking Peptide - LS-E30790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PLEKHO1 / CKIP-1 Antibody Blocking Peptide - LS-E9603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLEKHO1 / CKIP-1 Antibody Blocking Peptide - LS-E17338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CKIP-1 Protein - H00051177-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CKIP-1 Blocking Peptide - NBP1-76238PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

CKIP-1-Antibody-N-term-Blocking-Peptide - BP8500a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CKIP1 Peptide - GTX85240-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

CKIP-1 peptide - orb72543 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

PLEKHO1 Blocking Peptide - 33R-6233 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PLEKHO1 / CKIP1 - H00051177-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLEKHO1 / CKIP1 - H00051177-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLEKHO1 / CKIP1 Control Peptide - AP30235CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CKIP1 Peptide - 5435P from ProSci Category Peptide Species Human

PLEKHO1 fusion protein - Ag19309 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PLEKHO1 fusion protein - ag19601 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Pleckstrin homology domain-containing family O member 1(PLEKHO1) - CSB-YP706633HU CSB-EP706633HU CSB-BP706633HU CSB-MP706633HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PLEKHO1 / CKIP1 - TP303969 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Pleckstrin homology domain-containing family O member 1 (PLEKHO1), Recombinant Protein - MBS1301447 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,900.00, $1,900.00, $2,365.00, $2,365.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PLEKHO1 Peptide, Human - M34GP11950H from Creative Peptides Category Peptide Source Synthetic. Species Human

CKIP-1 Recombinant Protein Antigen - NBP2-57588PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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