| Gene Symbol | Casp4 |
|---|---|
| Entrez Gene | 12363 |
| Alt Symbol | CASP-11, CASP-4, Casp11, Caspl, ich-3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | caspase 4, apoptosis-related cysteine peptidase |
| Other Description | caspase 11, apoptosis-related cysteine peptidase|caspase 11, apoptosis-related cysteine protease|caspase 4, apoptosis-related cysteine protease|caspase-11 short form splicing|caspase-4|protease ICH-3 |
| Swissprots | P70343 O08735 Q3TAF3 |
| Accessions | EDL09318 EDL09319 P70343 AB480706 BAH96541 AK078836 AK138730 AK151547 BAE30493 AK156667 AK160328 AK171877 BAE42715 BC061255 AAH61255 BF018212 U59463 AAB09469 Y13089 CAA73531 XM_006509837 XP_006509900 XM_006509838 XP_006509901 XM_006509839 XP_006509902 NM_007609 NP_031635 |
| Function | Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses. {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion {ECO:0000250}. |
| Tissue Specificity | Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain. |