| Gene Symbol |
M6pr
|
| Entrez Gene |
312689
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
mannose-6-phosphate receptor, cation dependent
|
| Other Description |
CD Man-6-P receptor|CD-MPR|cation-dependent mannose-6-phosphate receptor
|
| Swissprots |
Q6AY20
|
| Accessions |
EDM01998 EDM01999 Q6AY20 BC079226 AAH79226 XM_008763247 XP_008761469 XM_008763248 XP_008761470 NM_001007700 NP_001007701
|
| Function |
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Lysosome, Phagosome
|