| Gene Symbol | M6pr |
|---|---|
| Entrez Gene | 312689 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | mannose-6-phosphate receptor, cation dependent |
| Other Description | CD Man-6-P receptor|CD-MPR|cation-dependent mannose-6-phosphate receptor |
| Swissprots | Q6AY20 |
| Accessions | EDM01998 EDM01999 Q6AY20 BC079226 AAH79226 XM_008763247 XP_008761469 XM_008763248 XP_008761470 NM_001007700 NP_001007701 |
| Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Lysosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Top Pathways | Lysosome, Phagosome |
CompoZr® Knockout ZFN Kit - CKOZFN56874 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND56874 from Sigma-Aldrich
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M6PR siRNA (Rat) - CRR5382 from Cohesion Biosciences
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shRNA set against Rat M6PR (NM_001007700.1) - SHH336395 from Creative biogene
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shRNA set against Rat M6pr(NM_001007700.1) - SHH169567 from Creative biogene
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M6PR shRNA Plasmid (Rat) - CHR5382 from Cohesion Biosciences
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M6PR miRNA 3'UTR clone - MiUTR1R-03638 from Creative biogene
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