PARP3

Gene Symbol	PARP3
Entrez Gene	10039
Alt Symbol	ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
Species	Human
Gene Type	protein-coding
Description	poly (ADP-ribose) polymerase family, member 3
Other Description	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|ADP-ribosyltransferase diphtheria toxin-like 3|ADPRT-3|NAD(+) ADP-ribosyltransferase 3|NAD+ ADP-ribosyltransferase 3|poly [ADP-ribose] polymerase 3|poly(ADP-ribose) synthetase-3|poly[ADP-ribose] synthase 3|poly[ADP-ribose] synthetase 3
Swissprots	Q9Y6F1 Q9UG81 Q96CG2 Q8NER9
Accessions	CAC07443 CAC07444 EAW65160 EAW65161 EAW65162 EAW65163 Q9Y6F1 AB208803 BAD92040 AF083068 AAD29855 AI088919 AL050034 CAB43246 AY126341 AAM95460 BC014260 AAH14260 BF375394 BG818516 BI554046 BU632340 CA309713 CA394313 JF432226 ADZ15443 Y16836 CAC79988 XM_005264779 XP_005264836 XM_011533257 XP_011531559 XM_011533258 XP_011531560 NM_001003931 NP_001003931 NM_005485 NP_005476 NM_001003935
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}.
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
Tissue Specificity	Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PARP3-cDNA-Clone - DC03799 from Abgent, a WuXi AppTec company Prices $719.55 Sizes 10 µg Species Human Accession BC014260

Human PARP3 cDNA clone(NM_001003931.2) - CDFH013718 from Creative Biomart Species Human Accession NM_001003931.2

Human PARP3 cDNA clone(NM_005485.4) - CDFH013719 from Creative Biomart Species Human Accession NM_005485.4

Human PARP3 ORF clone(NM_005485.4) - CDCL185614 from Creative Biomart Species Human Accession NM_005485.4

Human PARP3 ORF Clone(NM_005485.4) - CDCR290600 from Creative Biomart Species Human Accession NM_005485.4

Human PARP3 ORF Clone(NM_005485.4) - CDCR290601 from Creative Biomart Species Human Accession NM_005485.4

Human PARP3 ORF Clone(NM_005485.4) - CDCR290602 from Creative Biomart Species Human Accession NM_005485.4

Human PARP3 ORF Clone(NM_001003931.2) - CDCR339028 from Creative Biomart Species Human Accession NM_001003931.2

Human PARP3 ORF Clone(NM_001003931.2) - CDCR339029 from Creative Biomart Species Human Accession NM_001003931.2

Human PARP3 transcript variant 2 Gene ORF cDNA clone in cloning vector - HG11190-M from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11190-NF from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11190-NM from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11190-CF from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11190-NY from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11190-NH from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11190-CM from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11190-M-F from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11190-M-N from Sino Biological Species Human Accession NM_005485.4

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11190-CH from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11190-CY from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tag - HG11190-ACR from Sino Biological Species Human Accession NM_005485.4

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11190-ANR from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid - HG11190-UT from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11190-ANG from Sino Biological Species Human

Human PARP3 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11190-ACG from Sino Biological Species Human

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