| Gene Symbol |
PARP3
|
| Entrez Gene |
10039
|
| Alt Symbol |
ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) polymerase family, member 3
|
| Other Description |
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|ADP-ribosyltransferase diphtheria toxin-like 3|ADPRT-3|NAD(+) ADP-ribosyltransferase 3|NAD+ ADP-ribosyltransferase 3|poly [ADP-ribose] polymerase 3|poly(ADP-ribose) synthetase-3|poly[ADP-ribose] synthase 3|poly[ADP-ribose] synthetase 3
|
| Swissprots |
Q9Y6F1 Q9UG81 Q96CG2 Q8NER9
|
| Accessions |
CAC07443 CAC07444 EAW65160 EAW65161 EAW65162 EAW65163 Q9Y6F1 AB208803 BAD92040 AF083068 AAD29855 AI088919 AL050034 CAB43246 AY126341 AAM95460 BC014260 AAH14260 BF375394 BG818516 BI554046 BU632340 CA309713 CA394313 JF432226 ADZ15443 Y16836 CAC79988 XM_005264779 XP_005264836 XM_011533257 XP_011531559 XM_011533258 XP_011531560 NM_001003931 NP_001003931 NM_005485 NP_005476 NM_001003935
|
| Function |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
|
| Tissue Specificity |
Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
|
| Top Pathways |
Base excision repair
|
![Western Blot: PARP3 Antibody [NBP1-31415] - A. A431 whole cell lysate/extract, B. HeLa whole cell lysate/extract, C. A37C whole cell lysate/extract. 7.5 % SDS-PAGE PARP3 antibody dilution: 1:1000](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_8/832_PARP3-Antibody-Western-Blot-NBP1-31415-img0021.jpg)
![Western Blot: PARP3 Antibody [NBP1-53011] - HepG2 cell lysate, Antibody Titration: 0.2-1 ug/ml](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_2/9829_PARP3%2520Antibody-Western%2520Blot-NBP1-53011-img0001.jpg)
![Western Blot: PARP3 Antibody [H00010039-B01P] - analysis of PARP3 expression in transfected 293T cell line by PARP3 MaxPab polyclonal antibody. Lane 1: PARP3 transfected lysate (58.63 KDa). Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_4/9427_PARP3-Antibody-Western-Blot-H00010039-B01P-img0001.jpg)
![Immunohistochemistry-Paraffin: PARP3 Antibody [NBP1-66533] - Analysis of paraffin-embedded human brain, using PARP3 Antibody. The picture on the right is treated with the synthesized peptide.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_5/2788_PARP3%2520Antibody-Immunohistochemistry-Paraffin-NBP1-66533-img0001.jpg)