PARP3

Gene Symbol	PARP3
Entrez Gene	10039
Alt Symbol	ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
Species	Human
Gene Type	protein-coding
Description	poly (ADP-ribose) polymerase family, member 3
Other Description	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|ADP-ribosyltransferase diphtheria toxin-like 3|ADPRT-3|NAD(+) ADP-ribosyltransferase 3|NAD+ ADP-ribosyltransferase 3|poly [ADP-ribose] polymerase 3|poly(ADP-ribose) synthetase-3|poly[ADP-ribose] synthase 3|poly[ADP-ribose] synthetase 3
Swissprots	Q9Y6F1 Q9UG81 Q96CG2 Q8NER9
Accessions	CAC07443 CAC07444 EAW65160 EAW65161 EAW65162 EAW65163 Q9Y6F1 AB208803 BAD92040 AF083068 AAD29855 AI088919 AL050034 CAB43246 AY126341 AAM95460 BC014260 AAH14260 BF375394 BG818516 BI554046 BU632340 CA309713 CA394313 JF432226 ADZ15443 Y16836 CAC79988 XM_005264779 XP_005264836 XM_011533257 XP_011531559 XM_011533258 XP_011531560 NM_001003931 NP_001003931 NM_005485 NP_005476 NM_001003935
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}.
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
Tissue Specificity	Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PARP3 full length protein - ab79638 from Abcam Category Protein Prices $471.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PARP3 full length protein - ab160772 from Abcam Category Protein Source Wheat germ Species Human

Human PARP3 full length protein - ab157269 from Abcam Category Protein Source Baculovirus infected Sf21 cells Species Human

PARP3 Antibody Blocking Peptide - LS-E11945 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARP3 Antibody Blocking Peptide - LS-E26920 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PARP3 Protein - H00010039-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PARP3 blocking peptide - GTX88528-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PARP3 Blocking Peptide - 33R-4994 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PARP3 Peptide - AC21-1751-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PARP3 - H00010039-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PARP3 - H00010039-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PARP3 Peptide - 46-753P from ProSci Category Peptide

PARP3 fusion protein - Ag1844 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Poly (ADP-ribose) Polymerase 3, GST-tagged - PARP3-434H from Creative Biomart Category Protein Source Sf9 cell.

Recombinant Human PARP3 Protein, His-tagged - PARP3-642H from Creative Biomart Category Protein Source Insect Cells Species Human

Recombinant Human PARP3, GST-tagged - PARP3-27634TH from Creative Biomart Category Protein

Recombinant Human PARP3, HA-tagged - PARP3-454H from Creative Biomart Category Protein Source Baculovirus infected Sf21 Cells Species Human

Recombinant Human PARP3, GST-tagged - PARP3-1533H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PARP-3 - PARP3-59H from Creative Biomart Category Protein Source Sf9 cells Species Human

Human PARP-3 / PARP3 Protein (His & GST Tag) - 11190-H20B-100 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Baculovirus-Insect Cells Species Human

PARP3 Blocking Peptide - CBP4145 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PARP-3 [ARTD3] (high purity) - pro10402 from Covalab Category Protein Source Sf21 cells Species Human

PARP3 (transcript variant 2) - TP304308 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PARP3, Peptide - MBS425853 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human PARP-3 / PARP3 Protein (His & GST tag) - PKSH031216 from Elabscience Category Protein Source Baculoviru Species Human

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