GRIN1

Gene Symbol GRIN1
Entrez Gene 2902
Alt Symbol GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, N-methyl D-aspartate 1
Other Description N-methyl-D-aspartate receptor channel, subunit zeta-1|N-methyl-D-aspartate receptor subunit NR1|glutamate [NMDA] receptor subunit zeta 1|glutamate [NMDA] receptor subunit zeta-1|glutamate receptor ionotropic, NMDA 1
Swissprots Q5VSF6 Q5VSF3 A6NLK7 Q5VSF5 Q12868 Q9UPF9 Q05586 Q12867 Q5VSF4 A6NLR1 Q5VSF8 P35437 Q9UPF8 Q5VSF7 C9K0X1
Accessions EAW88350 EAW88351 EAW88352 EAW88353 EAW88354 EAW88355 EAW88356 EAW88357 EAW88358 EAW88359 EAW88360 Q05586 AB208918 BAD92155 AB208999 BAD92236 AF015730 AAB67723 AF015731 AAB67724 BC156097 AAI56098 BC156961 AAI56962 BU728516 D13515 BAA02732 L05666 AAA21180 L13266 AAB59360 L13267 AAA36198 L13268 AAB59361 S57708 AAB25917 U08106 AAA62111 U08107 AAA62112 XM_005266071 XP_005266128 XM_005266072 XP_005266129 XM_005266073 XP_005266130 XM_011518583 XP_011516885 NM_000832 NP_000823 NM_001185090 NP_001172019 NM_001185091 NP_001172020 NM_007327 NP_015566 NM_021569 NP_067544
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.
Top Pathways Amphetamine addiction, Circadian entrainment, Alcoholism, cAMP signaling pathway, Rap1 signaling pathway

Phospho-NMDAR1 (Ser890) Antibody - 3381 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from parental (COS) or NMDAR1-transfected (COS/NMDAR1) cells, untreated or TPA-treated (100 nM for 5 minutes), using Phospho-NMDAR1 (Ser890) Antibody.

Phospho-NMDAR1 (Ser896) Antibody - 3384 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from parental (COS) or NMDAR1-transfected (COS/NMDAR1) cells, untreated or TPA-treated (100 nM for 5 minutes), using Phospho-NMDAR1 (Ser896) Antibody.

Phospho-NMDAR1 (Ser897) Antibody - 3385 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from parental (COS) or NMDAR1-transfected (COS/NMDAR1) cells, untreated or forskolin-treated (30 µM of for 20 minutes), using Phospho-NMDAR1 (Ser897) Antibody.

NMDAR1 (D65B7) Rabbit mAb - 5704 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D65B7
Western blot analysis of extracts from rat and mouse brain using NMDAR1 (D65B7) Rabbit mAb.

NMDAR1 Antibody - 4204 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U87-MG and SH-SY5Y cells, using NMDAR1 Antibody.

NMDAζ1 (C-20) - sc-1467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NMDAζ1 (C-20): sc-1467. Western blot analysis of glutamate (NMDA) receptor zeta 1 expression in total mouse brain (A) and mouse cerebellum (B) extracts.

NMDAζ1 (R-20) - sc-31556 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NMDAζ1 (H-300) - sc-9058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NMDAζ1 (H-300): sc-9058. Western blot analysis of NMDAζ1 expression in mouse brain extract.

NMDAζ1 (V-20) - sc-31557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NMDAζ1 (V-20): sc-31557. Western blot analysis of NMDAζ1 expression in BC<sub>3</sub>H1 (A) and EOC 20 (B) whole cell lysates.

p-NMDAζ1 (Ser 896) - sc-31669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NMDAζ1 (Ser 896): sc-31669. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic staining of neuronal cells.

p-NMDAζ1 (Ser 896) - sc-101757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-NMDAζ1 (Ser 896): sc-101757. Western blot analysis of phosphorylated NMDAζ1 expression in untreated (A) and estradiol-treated (B) MCF7 whole cell lysates.

p-NMDAζ1 (Ser 896/897) - sc-12890 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NMDAR1 (phospho S889) antibody [EPR2480Y] - ab68144 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2480Y
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab68144 at a dilution of 1/100 - 1/250.

Anti-NMDAR1 (phospho S890) antibody - ab111566 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111566, at 1/50 dilution, staining NMDAR1 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-NMDAR1 (phospho S890) antibody - ab196010 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NMDAR1 (phospho S890) antibody (ab196010) at 1/500 dilutionLane 1 : A549 whole cell lysates with antigen-specific peptideLane 2 : A549 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-NMDAR1 (phospho S890) antibody - ab195002 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NMDAR1 (phospho S890) antibody (ab195002) at 1/500 dilutionLane 1 : A540 cell extractLane 2 : A540 cell extract with antigen-specific peptide

Anti-NMDAR1 (phospho S896) antibody - ab75680 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NMDAR1 (phospho S896) antibody (ab75680) at 1/500 dilutionLane 1 : MCF7 cell extracts, untreatedLane 2 : MCF7 cell extracts, treated with estradiol (100nM, 20min)

Anti-NMDAR1 (phospho S897) antibody - ab52184 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab52184 at 1/50 dilution staining Human brain tissue with and without blocking peptide; paraffin embedded.

Anti-NMDAR1 (phospho S897) antibody - ab195941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NMDAR1 (phospho S897) antibody (ab195941) at 1/500 dilutionLane 1 : LOVO whole cell lysates with antigen-specific peptideLane 2 : LOVO whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-NMDAR1 antibody - ab52177 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab52177 at 1/50 dilution staining NMDAR1 in human brain tissue by immunohistochemistry, paraffin embedded tissue in the presence (right image) or absence (left image) of the immunisng peptide.

Anti-NMDAR1 antibody - ab131452 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol fixed HeLa cells labelling NMDAR1 with ab131452 antibody at a dilution of 1/100.

Anti-NMDAR1 antibody - ab59302 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab59302 at 1/50-1/100 dilution staining human brain tissue without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-NMDAR1 antibody [0.T.190] - ab32915 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 0.T.190

Anti-NMDAR1 antibody [2Q155] - ab64572 from Abcam

Prices $372.00
Sizes 125 µg
Host Mouse
Clonality Monoclonal
Clone 2Q155

Anti-NMDAR1 antibody [EPR2481(2)] - ab109182 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2481(2)
All lanes : Anti-NMDAR1 antibody [EPR2481(2)] (ab109182) at 1/5000 dilution (purified)Lane 1 : Mouse brain tissue lysateLane 2 : Rat brain tissue lysateLysates/proteins at 20 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution
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