| Gene Symbol |
GRIN1
|
| Entrez Gene |
2902
|
| Alt Symbol |
GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 1
|
| Other Description |
N-methyl-D-aspartate receptor channel, subunit zeta-1|N-methyl-D-aspartate receptor subunit NR1|glutamate [NMDA] receptor subunit zeta 1|glutamate [NMDA] receptor subunit zeta-1|glutamate receptor ionotropic, NMDA 1
|
| Swissprots |
Q5VSF6 Q5VSF3 A6NLK7 Q5VSF5 Q12868 Q9UPF9 Q05586 Q12867 Q5VSF4 A6NLR1 Q5VSF8 P35437 Q9UPF8 Q5VSF7 C9K0X1
|
| Accessions |
EAW88350 EAW88351 EAW88352 EAW88353 EAW88354 EAW88355 EAW88356 EAW88357 EAW88358 EAW88359 EAW88360 Q05586 AB208918 BAD92155 AB208999 BAD92236 AF015730 AAB67723 AF015731 AAB67724 BC156097 AAI56098 BC156961 AAI56962 BU728516 D13515 BAA02732 L05666 AAA21180 L13266 AAB59360 L13267 AAA36198 L13268 AAB59361 S57708 AAB25917 U08106 AAA62111 U08107 AAA62112 XM_005266071 XP_005266128 XM_005266072 XP_005266129 XM_005266073 XP_005266130 XM_011518583 XP_011516885 NM_000832 NP_000823 NM_001185090 NP_001172019 NM_001185091 NP_001172020 NM_007327 NP_015566 NM_021569 NP_067544
|
| Function |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.
|
| Top Pathways |
Amphetamine addiction, Circadian entrainment, Alcoholism, cAMP signaling pathway, Rap1 signaling pathway
|