DNM2
| Gene Symbol | DNM2 |
|---|---|
| Entrez Gene | 1785 |
| Alt Symbol | CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynamin 2 |
| Other Description | dynamin II|dynamin-2 |
| Swissprots | A8K1B6 Q7Z5S3 Q9UPH4 Q5I0Y0 K7ESI9 E7EV30 P50570 E9PEQ4 |
| Accessions | AAD23603 AAD23604 EAW84144 EAW84145 EAW84146 EAW84147 EAW84148 EAW84149 EAW84150 EAW84151 P50570 AB209213 BAD92450 AK023207 AK094984 BAG52966 AK097875 BAC05190 AK097967 AK097989 BAG53560 AK124881 BAC85978 AK126192 BAC86481 AK127033 BAC86797 AK289831 BAF82520 AK295929 BAG58715 AK312260 AY927542 BC039596 AAH39596 BC054501 AAH54501 BM148999 BU621654 DB069057 DQ594929 L36983 AAA88025 NM_001005360 NP_001005360 NM_001005361 NP_001005361 NM_001005362 NP_001005362 NM_001190716 NP_001177645 NM_004945 NP_004936 |
| Function | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. {ECO:0000250|UniProtKB:P39052, ECO:0000269|PubMed:12498685}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:P39052}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P39052}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Midbody. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. {ECO:0000250|UniProtKB:P39052}. |
| Tissue Specificity | Ubiquitously expressed. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Endocytosis, Bacterial invasion of epithelial cells, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle |
Dynamin II CRISPR/Cas9 KO Plasmid (h) - sc-401037 from Santa Cruz Biotechnology
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Dynamin II HDR Plasmid (h) - sc-401037-HDR from Santa Cruz Biotechnology
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Dynamin II Double Nickase Plasmid (h) - sc-401037-NIC from Santa Cruz Biotechnology
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Dynamin II Double Nickase Plasmid (h2) - sc-401037-NIC-2 from Santa Cruz Biotechnology
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Dynamin II CRISPR Activation Plasmid (h) - sc-401037-ACT from Santa Cruz Biotechnology
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Dynamin II CRISPR Activation Plasmid (h2) - sc-401037-ACT-2 from Santa Cruz Biotechnology
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Dynamin II Lentiviral Activation Particles (h) - sc-401037-LAC from Santa Cruz Biotechnology
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Dynamin II Lentiviral Activation Particles (h2) - sc-401037-LAC-2 from Santa Cruz Biotechnology
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Dynamin II siRNA (h) - sc-35236 from Santa Cruz Biotechnology
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Dynamin II shRNA Plasmid (h) - sc-35236-SH from Santa Cruz Biotechnology
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Dynamin II shRNA (h) Lentiviral Particles - sc-35236-V from Santa Cruz Biotechnology
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Dynamin 2 RNAi - H00001785-R05 from Novus Biologicals
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Dynamin 2 RNAi - H00001785-R07 from Novus Biologicals
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Dynamin 2 RNAi - H00001785-R06 from Novus Biologicals
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Dynamin 2 RNAi - H00001785-R08 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7402 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7402 from Sigma-Aldrich
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DNM2 siRNA (Human) - CRH1240 from Cohesion Biosciences
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DNM2 - MBS8202844 from MyBioSource
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DNM2 shRNA Plasmid (Human) - CHH1240 from Cohesion Biosciences
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DNM2 miRNA 3'UTR clone - MiUTR3H-04928 from Creative biogene
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DNM2 miRNA 3'UTR clone - MiUTR3H-04929 from Creative biogene
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DNM2 miRNA 3'UTR clone - MiUTR3H-04930 from Creative biogene
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DNM2 miRNA 3'UTR clone - MiUTR3H-04931 from Creative biogene
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