| Gene Symbol |
ZBTB7A
|
| Entrez Gene |
51341
|
| Alt Symbol |
FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger and BTB domain containing 7A
|
| Other Description |
HIV-1 1st-binding protein 1|HIV-1 inducer of short transcripts binding protein|POK erythroid myeloid ontogenic factor|POZ and Krueppel erythroid myeloid ontogenic factor|TIP21|TTF-I-interacting peptide 21|factor binding IST protein 1|factor that binds to inducer of short transcripts protein 1|leukemia/lymphoma-related factor|lymphoma related factor|zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein|zinc finger and BTB domain-containing protein 7A|zinc finger protein 857A
|
| Swissprots |
Q5XG86 O00456 O95365 Q14D41 D6W619
|
| Accessions |
EAW69266 EAW69267 EAW69268 EAW69269 EAW69270 EAW69271 EAW69272 O95365 AF000561 AAB58414 AF097916 AAC72973 AL390151 BC019108 AAH19108 BC080608 BC084568 AAH84568 BC113511 AAI13512 BM696365 BQ082585 BQ711712 CB047382 CB242327 XM_005259570 XP_005259627 XM_005259571 XP_005259628 XM_005259572 XP_005259629 NM_015898 NP_056982
|
| Function |
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). {ECO:0000269|PubMed:15662416, ECO:0000269|PubMed:9927193}.
|