Gene Symbol | ZBTB7A |
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Entrez Gene | 51341 |
Alt Symbol | FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger and BTB domain containing 7A |
Other Description | HIV-1 1st-binding protein 1|HIV-1 inducer of short transcripts binding protein|POK erythroid myeloid ontogenic factor|POZ and Krueppel erythroid myeloid ontogenic factor|TIP21|TTF-I-interacting peptide 21|factor binding IST protein 1|factor that binds to inducer of short transcripts protein 1|leukemia/lymphoma-related factor|lymphoma related factor|zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein|zinc finger and BTB domain-containing protein 7A|zinc finger protein 857A |
Swissprots | Q5XG86 O00456 O95365 Q14D41 D6W619 |
Accessions | EAW69266 EAW69267 EAW69268 EAW69269 EAW69270 EAW69271 EAW69272 O95365 AF000561 AAB58414 AF097916 AAC72973 AL390151 BC019108 AAH19108 BC080608 BC084568 AAH84568 BC113511 AAI13512 BM696365 BQ082585 BQ711712 CB047382 CB242327 XM_005259570 XP_005259627 XM_005259571 XP_005259628 XM_005259572 XP_005259629 NM_015898 NP_056982 |
Function | Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). {ECO:0000269|PubMed:15662416, ECO:0000269|PubMed:9927193}. |
Human Pokemon peptide - ab23084 from Abcam
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Human ZBTB7A full length protein - ab132406 from Abcam
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E3071 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E14144 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E14143 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E31060 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E12788 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E13308 from LifeSpan Bioscience
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ZBTB7A / Pokemon Antibody Blocking Peptide - LS-E13545 from LifeSpan Bioscience
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Recombinant Human ZBTB7A/Pokemon Protein - H00051341-P01 from Novus Biologicals
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ZBTB7A/Pokemon Blocking Peptide - NBP1-76520PEP from Novus Biologicals
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ZBTB7A-Antibody-C-term-Blocking-Peptide - BP14208b from Abgent, a WuXi AppTec company
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Pokemon Blocking Peptide - abx161197 from Abbexa
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ZBTB7A / Pokemon - H00051341-P01-10 from Acris Antibodies
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ZBTB7A / Pokemon - H00051341-P01-25 from Acris Antibodies
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ZBTB7A / Pokemon Control Peptide - AP26085CP-N from Acris Antibodies
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ZBTB7A Peptide - 6127P from ProSci
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ZBTB7A fusion protein - ag13291 from Proteintech Group
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ZBTB7A fusion protein - ag13262 from Proteintech Group
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Recombinant Human ZBTB7A, His-tagged - ZBTB7A-2428H from Creative Biomart
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Pokemon Blocking Peptide - CBP3696 from Cohesion Biosciences
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Recombinant Human Zinc finger and BTB domain-containing protein 7A(ZBTB7A) - CSB-YP026343HU CSB-EP026343HU CSB-BP026343HU CSB-MP026343HU from Cusabio
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ZBTB7A / Pokemon - TP322759 from Acris Antibodies
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Zinc finger and BTB domain-containing protein 7A (ZBTB7A) , Recombinant Protein - MBS1088893 from MyBioSource
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TIP21, Peptide - MBS633967 from MyBioSource
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