| Gene Symbol |
NLRP10
|
| Entrez Gene |
338322
|
| Alt Symbol |
CLR11.1, NALP10, NOD8, PAN5, PYNOD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 10
|
| Other Description |
NACHT, LRR and PYD domains-containing protein 10|NACHT, leucine rich repeat and PYD containing 10|nucleotide-binding oligomerization domain protein 8|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
|
| Swissprots |
Q86W26 Q2M3C4 Q6JGT0
|
| Accessions |
EAW68640 Q86W26 AY154465 AAO18161 AY489192 AAS67384 BC104957 AAI04958 BK001110 DAA01243 XM_011520043 XP_011518345 XM_011546581 XP_011544883 XM_011548868 XP_011547170 NM_176821 NP_789791
|
| Function |
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
|
| Tissue Specificity |
Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:22672233}.
|