NLRP10

Gene Symbol NLRP10
Entrez Gene 338322
Alt Symbol CLR11.1, NALP10, NOD8, PAN5, PYNOD
Species Human
Gene Type protein-coding
Description NLR family, pyrin domain containing 10
Other Description NACHT, LRR and PYD domains-containing protein 10|NACHT, leucine rich repeat and PYD containing 10|nucleotide-binding oligomerization domain protein 8|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Swissprots Q86W26 Q2M3C4 Q6JGT0
Accessions EAW68640 Q86W26 AY154465 AAO18161 AY489192 AAS67384 BC104957 AAI04958 BK001110 DAA01243 XM_011520043 XP_011518345 XM_011546581 XP_011544883 XM_011548868 XP_011547170 NM_176821 NP_789791
Function Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
Tissue Specificity Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:22672233}.

NALP10 (P-20) - sc-50608 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NALP10 (Q-20) - sc-50609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NALP10 (Q-20): sc-50609. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-NLRP10 antibody - ab105407 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of NLRP10 in Human brain tissue with ab105407 at 20 ug/mL.

Anti-NLRP10 antibody - ab115966 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NLRP10 antibody (ab115966) at 1/100 dilution + Human placenta tissue lysates at 35 µg

Anti-NLRP10 antibody - N-terminal - ab198810 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NLRP10 antibody - N-terminal (ab198810) at 1/300 dilutionLane 1 : mouse heart tissue lysateLane 2 : mouse skeletal muscle tissue lysateLysates/proteins at 40 µg per lane.

Anti-NOD8 / NLRP10 Antibody (N-Terminus) IHC-plus™ - LS-B5332 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NLRP10 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5332 concentration 5 ug/ml.

Anti-NOD8 / NLRP10 Antibody (aa386-655, clone 11n133) - LS-C184851 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n133

Anti-NOD8 / NLRP10 Antibody (aa466-494, AP) - LS-C238083 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa466-494, Biotin) - LS-C238085 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa466-494, APC) - LS-C238084 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa466-494, FITC) - LS-C238086 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa493-509) - LS-C148531 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NALP10 in HeLa cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW cell lysate using LS-C148531 at 1.0 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-NOD8 / NLRP10 Antibody (aa466-494, Azide-free, HRP) - LS-C248927 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa466-494, PE) - LS-C246614 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa465-494) - LS-C323370 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD8 / NLRP10 Antibody (aa466-494) - LS-C164906 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NLRP10 Antibody western blot of human placenta tissue lysates (35 ug/lane). The NLRP10 antibody detected the NLRP10 protein (arrow).

NLRP10/Pynod/NALP10 Antibody (578502) - MAB6606 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 578502
Western blot shows lysates of Jurkat human acute T cell leukemia cell line, HT‑2 mouse T cell line, and L6 rat myoblast cell line. PVDF Membrane was probed with 0.5 µg/mL of Human/Mouse/Rat NLRP10/Pynod/NALP10 Monoclonal Antibody (Catalog # MAB6606) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for NLRP10/Pynod/NALP10 at approximately 80 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

NLRP10/Pynod/NALP10 Antibody - NBP2-24606 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

NLRP10/Pynod/NALP10 Antibody - NBP1-85557 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NLRP10/Pynod/NALP10 Antibody [NBP1-85557] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

NLRP10/Pynod/NALP10 Antibody - NBP1-85556 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: NLRP10/Pynod/NALP10 Antibody [NBP1-85556] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli.

NLRP10/Pynod/NALP10 Antibody - NBP1-76291 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NLRP10 antibody produced in rabbit - HPA039498 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NLRP10: <B>Cat. No. HPA039498</B>: Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in neuronal cells.

Anti-NLRP10 antibody produced in rabbit - HPA040101 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NLRP10: <B>Cat. No. HPA040101</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

Anti-NLRP10 (111-125) antibody produced in rabbit - SAB1103683 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NLRP10 was separated on SDS-PAGE, blotted with Anti-NLRP10 (111-125) (<B>Cat. No. SAB1103683</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + NLRP10 immunizing peptide (human, 111-125)

Anti-NALP10 antibody produced in rabbit - SAB3500553 from Sigma-Aldrich

Prices $346.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NALP10: <B>Cat. No. SAB3500553</B>: NALP10 in human brain tissue lysate with NALP10 antibody at 1 μg/mL.
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